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A First Course in Systems Biology
  • Language: en
  • Pages: 481

A First Course in Systems Biology

A First Course in Systems Biology is an introduction for advanced undergraduate and graduate students to the growing field of systems biology. Its main focus is the development of computational models and their applications to diverse biological systems. The book begins with the fundamentals of modeling, then reviews features of the molecular inventories that bring biological systems to life and discusses case studies that represent some of the frontiers in systems biology and synthetic biology. In this way, it provides the reader with a comprehensive background and access to methods for executing standard systems biology tasks, understanding the modern literature, and launching into special...

Systems Biology
  • Language: en
  • Pages: 161

Systems Biology

  • Type: Book
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  • Published: 2020
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  • Publisher: Unknown

Systems biology utilises new computational tools to analyse biological processes on an extraordinary scale. We can now study complex biological phenomena within their natural contexts, applying a holistic, systems-based approach. This book explores what this interdisciplinary field is about, and how it will affect our understanding of life.

Computational Analysis of Biochemical Systems
  • Language: en
  • Pages: 556

Computational Analysis of Biochemical Systems

Teaches the use of modern computational methods for the analysis of biomedical systems using case studies and accompanying software.

The Inner Workings of Life
  • Language: en
  • Pages: 223

The Inner Workings of Life

An easy-to-read introductory text, comprised of concise vignettes that explain key concepts within systems biology without using jargon.

Lipidomics and Bioactive Lipids: Mass Spectrometry Based Lipid Analysis
  • Language: en
  • Pages: 432

Lipidomics and Bioactive Lipids: Mass Spectrometry Based Lipid Analysis

  • Type: Book
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  • Published: 2007-11-26
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  • Publisher: Elsevier

This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Qualitative Analysis and Quantitative Assessment of Changes in Neutral Glycerol Lipid Molecular Species within Cells; Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry; Detection and Quantitation of Eicosanoids via High Performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry; Structure-specific, quantitative methods for "lipidomic" analysis of sphingolipids by tandem mass spectrometry; Analysis of Ubiquinones, Dolichols and Dolichol Diphospha...

Pathway Analysis and Optimization in Metabolic Engineering
  • Language: en
  • Pages: 328

Pathway Analysis and Optimization in Metabolic Engineering

Facility in the targeted manipulation of the genetic and metabolic composition of organisms, combined with unprecedented computational power, is forging a niche for a new subspecialty of biotechnology called metabolic engineering. First published in 2002, this book introduces researchers and advanced students in biology and engineering to methods of optimizing biochemical systems of biotechnological relevance. It examines the development of strategies for manipulating metabolic pathways, demonstrates the need for effective systems models, and discusses their design and analysis, while placing special emphasis on optimization. The authors propose power-law models and methods of biochemical systems theory toward these ends. All concepts are derived from first principles, and the text is richly illustrated with numerous graphs and examples throughout. Special features include: nontechnical and technical introductions to models of biochemical systems; a review of basic methods of model design and analysis; concepts of optimization; and detailed case studies.

Foundations of Theoretical Approaches in Systems Biology
  • Language: en
  • Pages: 216

Foundations of Theoretical Approaches in Systems Biology

If biology in the 20th century was characterized by an explosion of new technologies and experimental methods, that of the 21st has seen an equally exuberant proliferation of mathematical and computational methods that attempt to systematize and explain the abundance of available data. As we live through the consolidation of a new paradigm where experimental data goes hand in hand with computational analysis, we contemplate the challenge of fusing these two aspects of the new biology into a consistent theoretical framework. Whether systems biology will survive as a field or be washed away by the tides of future fads will ultimately depend on its success to achieve this type of synthesis. The famous quote attributed to Kurt Lewin comes to mind: "there is nothing more practical than a good theory". This book presents a wide assortment of articles on systems biology in an attempt to capture the variety of current methods in systems biology and show how they can help to find answers to the challenges of modern biology.

Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis
  • Language: en
  • Pages: 342

Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis

It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

Methodologies For The Conception, Design, And Application Of Intelligent Systems - Proceedings Of The 4th International Conference On Soft Computing (In 2 Volumes)
  • Language: en
  • Pages: 1064

Methodologies For The Conception, Design, And Application Of Intelligent Systems - Proceedings Of The 4th International Conference On Soft Computing (In 2 Volumes)

IIZUKA '96, the 4th International Conference on Soft Computing, emphasized the integration of the components of soft computing to promote the research work on post-digital computers and to realize the intelligent systems. At the conference, new developments and results in soft computing were introduced and discussed by researchers from academic, governmental, and industrial institutions.This volume presents the opening lectures by Prof. Lotfi A. Zadeh and Prof. Walter J. Freeman, the plenary lectures by seven eminent researchers, and about 200 carefully selected papers drawn from more than 20 countries. It documents current research and in-depth studies on the conception, design, and application of intelligent systems.

Philosophy of Systems Biology
  • Language: en
  • Pages: 274

Philosophy of Systems Biology

  • Type: Book
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  • Published: 2016-12-15
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  • Publisher: Springer

The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers,...