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An investigation of microRNA target regulation mechanisms using an integrative approach
This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.
Systems Biology for Signaling Networks
System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems. Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signal...
Cancer Immunology
This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging. Cancer Immunology: A Translational Medicine Context will be of special value to clinical immunologists, hematologists, and oncologists.
Cancer Systems Biology, Bioinformatics and Medicine
This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods. Specifically, the book: 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches, and the clinical background of cancer in a systems context; 2) Summarizes the laboratory, clinical, data systems analysis and bioinformatics tools, along with infrastructure and resources required; 3) Demonstrates the application of these tools to cancer research; 4) Extends these ...
The Silver Tea Room
Destiny calling out across time. Two lovers separated by an untimely death. Hidden passions and desires and activities. The seduction and corruption of a family business. Eyes haunting the present and penetrating the past. The need to uncover buried truths and lies. How high a price is too much to pay to right a past injustice? Marise must soon answer how much she is willing to risk today to fix yesteryear..... Two lovers, Julio and Marise, are destined to be together in life and death. They're relationship culminates in the nineteen twenties around wealth, power, and illegal alcohol. The rum running exudes a seductive allure trying to capture all in its wake of desire.
Best Actress
Showcasing a dazzling collection of 200 photographs, many of which have never before been seen, this lavishly illustrated book offers a captivating historical, social, and political examination of the first 75 women--from Janet Gaynor to Emma Stone--to have won the coveted and legendary Academy Award for Best Actress.t Actress.
Rising Threats in Expert Applications and Solutions
This book presents high-quality, peer-reviewed papers from the FICR International Conference on Rising Threats in Expert Applications and Solutions 2020, held at IIS University Jaipur, Rajasthan, India, on January 17–19, 2020. Featuring innovative ideas from researchers, academics, industry professionals and students, the book covers a variety of topics, including expert applications and artificial intelligence/machine learning; advanced web technologies, like IoT, big data, and cloud computing in expert applications; information and cybersecurity threats and solutions; multimedia applications in forensics, security and intelligence; advances in app development; management practices for expert applications; and social and ethical aspects of expert applications in applied sciences.
Understanding the Geological and Medical Interface of Arsenic - As 2012
The congress "Arsenic in the Environment" offers an international, multi- and interdisciplinary discussion platform for arsenic research aimed at practical solutions of problems with considerable social impact, as well as focusing on cutting edge and breakthrough research in physical, chemical, toxicological, medical and other specific issues on arsenic on a broader environmental realm. The congress "Arsenic in the Environment" was first organized in Mexico City (As 2006) followed by As 2008 in Valencia, Spain and As 2010 in Tainan, Taiwan. The 4th International Congress As 2012 was held in Cairns, Australia from July 22-27, 2012 entitled Understanding the Geological and Medical Interface of...
Bioinformatics and Biomedical Engineering
This two-volume set LNBI 10813 and LNBI 10814 constitutes the proceedings of the 6th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2018, held in Granada, Spain, in April 2018.The 88 regular papers presented were carefully reviewed and selected from 273 submissions. The scope of the conference spans the following areas: bioinformatics for healthcare and diseases; bioinformatics tools to integrate omics dataset and address biological question; challenges and advances in measurement and self-parametrization of complex biological systems; computational genomics; computational proteomics; computational systems for modelling biological processes; drug delivery ...
Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications
"This book translates basic science discoveries into regenerative therapies with the application of clinical tool in aging and tissue regeneration"--
