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Iminosugars
Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of e...
Gaucher's Disease: New Insights for the Healthcare Professional: 2012 Edition
Gaucher's Disease: New Insights for the Healthcare Professional: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Gaucher Disease in a concise format. The editors have built Gaucher's Disease: New Insights for the Healthcare Professional: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Gaucher Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Gaucher's Disease: New Insights for the Healthcare Professional: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Handbook of Soil Sciences (Two Volume Set)
An evolving, living organic/inorganic covering, soil is in dynamic equilibrium with the atmosphere above, the biosphere within, and the geology below. It acts as an anchor for roots, a purveyor of water and nutrients, a residence for a vast community of microorganisms and animals, a sanitizer of the environment, and a source of raw materials for co
Spectroscopic Properties of Inorganic and Organometallic Compounds
Divided into sections mainly according to the particular spectroscopic technique used, researchers will find this an invaluable source of information on current methods and applications.
Nanopharmaceuticals: Principles and Applications Vol. 3
This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
The Alkaloids
This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. - Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective - Comprehensive dynamic reviews written by the leading authors in their respective fields - Broader coverage than before on the biological aspects
Rifting and Sediments in the Red Sea and Arabian Gulf Regions
Rifting and Sediments in the Red Sea and Arabian Gulf Regions is a unique text that covers a wide range of topics related to the tectonics and geology of the Red Sea and Arabian (Persian) Gulf region. This book is a collection of invited and peer-reviewed chapters contributed by active researchers around the world. The topics covered in this book include tectonics, magmatism, and lithology, particularly in the Red Sea area. The book also delves into the sediments and evaporites of the Red Sea and Gulf. As the area around the Arabian Peninsula is prone to earthquakes, the seismic hazard estimated in the Red Sea region is also covered by several chapters. Each chapter presents new data and offers extensive lists of references for the reader to explore further. With the ongoing debates regarding the structure of the Red Sea, this book serves as an excellent resource for researchers and any individuals interested in the geology of these two unique seas.
Reactive Transport Modeling
Teaches the application of Reactive Transport Modeling (RTM) for subsurface systems in order to expedite the understanding of the behavior of complex geological systems This book lays out the basic principles and approaches of Reactive Transport Modeling (RTM) for surface and subsurface environments, presenting specific workflows and applications. The techniques discussed are being increasingly commonly used in a wide range of research fields, and the information provided covers fundamental theory, practical issues in running reactive transport models, and how to apply techniques in specific areas. The need for RTM in engineered facilities, such as nuclear waste repositories or CO2 storage s...
Mont Terri Rock Laboratory, 20 Years
The international Mont Terri rock laboratory in Switzerland plays a central role in the safety and construction of deep geological nuclear repositories in clay formations. The laboratory has developed and refined a range of new measurement and evaluation methods: it has e.g. advanced the determination of rock parameters using innovative borehole geophysics, improved the methodology for characterizing pore-water and microbial activity in claystones, and greatly improved our understanding of diffusion and retention processes of radionuclides in and through claystones. The methods and insights described in this compendium can also be applied to low-permeability rocks at various sites around the globe, and in other fields of application.
Sphingolipid Metabolism and Metabolic Disease
This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.
