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The Logic of Chance
The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and hypotheses on the key aspects of the evolution of life on earth in light of comparative genomics and systems biology. The author presents many specific examples from systems and comparative genomic analysis to begin to build a new, much more detailed, complex, and realistic picture of evolution. The book examines a broad range of topics in evolutionary biology including the inadequacy of natural selection and adaptation as the only or even the main mode of evolution; the key role of horizontal gene transfer in evolution and the consequent overhaul of the Tree of Life concept; the central, underappreciated...
Sequence — Evolution — Function
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases....
Evolutionary Genomics
Together with early theoretical work in population genetics, the debate on sources of genetic makeup initiated by proponents of the neutral theory made a solid contribution to the spectacular growth in statistical methodologies for molecular evolution. Evolutionary Genomics: Statistical and Computational Methods is intended to bring together the more recent developments in the statistical methodology and the challenges that followed as a result of rapidly improving sequencing technologies. Presented by top scientists from a variety of disciplines, the collection includes a wide spectrum of articles encompassing theoretical works and hands-on tutorials, as well as many reviews with key biolog...
The Revolutionary Origins of Life and Death
The question of why an individual would actively kill itself has long been an evolutionary mystery. Pierre M. Durand’s ambitious book answers this question through close inspection of life and death in the earliest cellular life. As Durand shows us, cell death is a fascinating lens through which to examine the interconnectedness, in evolutionary terms, of life and death. It is a truism to note that one does not exist without the other, but just how does this play out in evolutionary history? These two processes have been studied from philosophical, theoretical, experimental, and genomic angles, but no one has yet integrated the information from these various disciplines. In this work, Dura...
The Origin and Evolution of Eukaryotes
All protists, fungi, animals, and plants on Earth are eukaryotes. Their cells possess membrane-bound organelles including a nucleus and mitochondria, distinct cytoskeletal features, and a unique chromosome structure that permits them to undergo mitosis or meiosis. The emergence of eukaryotic cells from prokaryotic ancestors about 2 billion years ago was a pivotal evolutionary transition in the history of life on Earth. But the change was abrupt, and few clues exist as to the nature of the intermediate stages. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines evolutionary scenarios that likely led to the emergence and rapid ev...
Power Laws, Scale-Free Networks and Genome Biology
Deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks. This book not only describes the interesting mathematical properties of biological networks, but moves beyond phenomenology, towards models of evolution capable of explaining the emergence of these features.
Unsettled (Updated and Expanded Edition)
In this updated and expanded edition of climate scientist Steven Koonin’s groundbreaking book, go behind the headlines to discover the latest eye-opening data about climate change—with unbiased facts and realistic steps for the future. "Greenland’s ice loss is accelerating." "Extreme temperatures are causing more fatalities." "Rapid 'climate action' is essential to avoid a future climate disaster." You've heard all this presented as fact. But according to science, all of these statements are profoundly misleading. With the new edition of Unsettled, Steven Koonin draws on decades of experience—including as a top science advisor to the Obama administration—to clear away the fog and e...
Why Evolution is True
For all the discussion in the media about creationism and 'Intelligent Design', virtually nothing has been said about the evidence in question - the evidence for evolution by natural selection. Yet, as this succinct and important book shows, that evidence is vast, varied, and magnificent, and drawn from many disparate fields of science. The very latest research is uncovering a stream of evidence revealing evolution in action - from the actual observation of a species splitting into two, to new fossil discoveries, to the deciphering of the evidence stored in our genome. Why Evolution is True weaves together the many threads of modern work in genetics, palaeontology, geology, molecular biology, anatomy, and development to demonstrate the 'indelible stamp' of the processes first proposed by Darwin. It is a crisp, lucid, and accessible statement that will leave no one with an open mind in any doubt about the truth of evolution.
The Edge of Evolution
The author of Darwin's Black Box draws on new findings in genetics to pose an argument for intelligent design that refutes Darwinian beliefs about evolution while offering alternative analyses of such factors as disease, random mutations, and the human struggle for survival. Reprint. 40,000 first printing.
Bioinformatics
"In this book, Andy Baxevanis and Francis Ouellette . . . haveundertaken the difficult task of organizing the knowledge in thisfield in a logical progression and presenting it in a digestibleform. And they have done an excellent job. This fine text will makea major impact on biological research and, in turn, on progress inbiomedicine. We are all in their debt." —Eric Lander from the Foreword Reviews from the First Edition "...provides a broad overview of the basic tools for sequenceanalysis ... For biologists approaching this subject for the firsttime, it will be a very useful handbook to keep on the shelf afterthe first reading, close to the computer." —Nature Structural Biology "...sho...
