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Syndromes of the Head and Neck
This classic text, one of the true anchors of our clinical genetics publishing program, covers over 700 different genetic syndromes involving the head and neck, and it has established itself as the definitive, comprehensive work on the subject. The discussion covers the phenotype spectrum, epidemiology, mode of inheritance, pathogenesis, and clinical profile of each condition, all of which is accompanied by a wealth of illustrations. The authors are recognized leaders in the field, and their vast knowledge and strong clinical judgment will help readers make sense of this complex and burgeoning field. Dr. Gorlin retires as editor in this edition and co-editor Raoul Hennekam takes over. Dr. He...
The Man Behind the Syndrome
The Man Behind the Syndrome by my friends and colleagues Peter and Greta Beighton is a delightful book which will be read eagedy and with keen intellectual pleasure by all human, medical, and dinical genetieists. The reader with a historical tum of mind will note right away that the book achieyes more than the usual entry in a dictionary of seientific biography. In addition to the standard professional data, it gives a photo and some personal glimpses of the man, allowing the reader to appreeiate his human qualities as weIl. This volume contains, so to speak, the creme de la creme, namely, those in a group whose names are daily on the lips of every practicing dinical geneticist. This interesting and instructive book is commended to all in medical genetics and the history of medieine with the highest enthusiasm and gratitude to its authors for undertaking this labor of love. A second volume is planned for more recently delineated disorders for which an eponym is not yet widely used.
Carbonate Sedimentology and Sequence Stratigraphy
Sedimentology and stratigraphy are neighbors yet distinctly separate entities within the earth sciences. Sedimentology searches for the common traits of sedimentary rocks regardless of age as it reconstructs environments and processes of deposition and erosion from the sediment record. Stratigraphy, by contrast, concentrates on changes with time, on measuring time and correlating coeval events. Sequence stratigraphy straddles the boundary between the two fields. This book, dedicated to carbonate rocks, approaches sequence stratigraphy from its sedimentologic background. This book attempts to communicate by combining different specialities and different lines of reasoning, and by searching for principles underlying the bewildering diversity of carbonate rocks. It provides enough general background, in introductory chapters and appendices, to be easily digestible for sedimentologists and stratigraphers as well as earth scientists at large.
Hereditary Hearing Loss and Its Syndromes
This is the third edition of the foremost medical reference on genetic hearing loss, updated to include new information on molecular mechanisms. It is an excellent resource for physicians, audiologists, and other professionals working with individuals with hearing loss and their families, and for clinical training programs and researchers in hearing sciences.
Sclerosing Bone Dysplasias
Much confusion exists in the accurate identification and classification of the many disorders in infancy which affect the skeleton by producing sclerosing lesions throughout the entire skeleton or in selected areas. A scholarly effort to bring order into this confusing field must be welcomed. Professors Beighton and Cremin have skillfully defined the problem and concisely yet thoroughly have identified the various sclerosing dysplasias. They bring to this task a wealth of clinical experience in their many years in the Departments of Radiology at the University of Cape Town Medical School and the Groote Schuur and Red Cross Children's Hospitals in Cape Town, South Africa. The authors also hav...
Lessons for Science from the Seven Countries Study
The Seven Countries Study has made central contributions to the under standing of the socio-cultural influences on population rates of cardiovascular diseases (CVD). It has pointed the way to preventive strategies for whole populations. The Study is unique as a long-term investigation, now in its 35th year. This pioneering work arose in part from a meeting between Professors Ancel Keys and Noboru Kimura to discuss differences observed in clinical mani festations and pathology of coronary disease in the U.S. and Japan. Professor Keys started explorations of the importance in these differences of dietary fat and serum cholesterol when he visited Japan in 1954, and thereafter initiated the Seven Countries Study to test these hypotheses. In the Japanese cohorts of the Study, it became evident from the outset that coronary artery disease was extremely rare, but its incidence has since increased along with dramatic lifestyle changes from traditional Japanese to western styles. The Japanese experience contrasts with a reduction in coronary artery disease in many western countries along with establishment of major preventive efforts in risk factor reduction and cardiac care.
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Foraminifera and their Applications
A one-stop practical guide to foraminifera with numerous case studies demonstrating their applications, for graduate students, micropalaeontologists and industry professionals.
Principles of Epidemiology
Principles of Epidemiology: A Self-Teaching Guide consists of a series of problem-solving exercises designed to introduce and guide readers toward an understanding of the principles and methods of epidemiology, rather than the epidemiology of specific diseases or subject areas such as ""infectious disease"" or ""chronic disease"" epidemiology. The guide has been formulated to be used by itself or as a supplement to standard textbooks. It illustrates and illuminates the principles and concepts of epidemiology and provides the reader an opportunity to practice the application of these principles in a logical sequence. The guide is divided into 14 exercises. Each exercise will help readers to understand principles or methods used by epidemiologist. Topics covered include the patterns of disease, populations at risk and risk assessment, screening for disease, investigation of an epidemic, etiology of disease, principles of causation, study design in epidemiologic investigation, data interpretation, and the uses and applications of epidemiology.
Prevention of Coronary Heart Disease: Diet, Lifestyle and Risk Factors in the Seven Countries Study
In the 1940s I was struck by reports about many apparently healthy middle-aged men who dropped dead instantly from heart attacks. The causes of these sudden deaths were unknown. I was interested to discover physio-chemical characteristics of individuals with predictive value for the occurrence of these fatal heart attacks. The discovery ofpreventive variables would point ways to prevent this disease. In order to find relationships between mode of life and susceptibility to heart disease contrasting populations had to be studied. Variety - not a high degree of homogeneity in culture and habits - must be sought. After exploratory surveys in countries with supposed differences in dietary patter...
