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Clinical Bioinformatics
In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.
Learning and Teaching Languages Through Content
Based on a synthesis of classroom SLA research that has helped to shape evolving perspectives of content-based instruction since the introduction of immersion programs in Montreal more than 40 years ago, this book presents an updated perspective on integrating language and content in ways that engage second language learners with language across the curriculum. A range of instructional practices observed in immersion and content-based classrooms is highlighted to set the stage for justifying a counterbalanced approach that integrates both content-based and form-focused instructional options as complementary ways of intervening to develop a learner’s interlanguage system. A counterbalanced approach is outlined as an array of opportunities for learners to process language through content by means of comprehension, awareness, and production mechanisms, and to negotiate language through content by means of interactional strategies involving teacher scaffolding and feedback.
Dermatological Emergencies
‘Dermatological Emergencies’ aims to cover aspects of situations and their management when they present in a Dermatology setup. This includes severe drug reactions, bullous disorders, erythroderma, infections, vasculitis and systemic emergencies presenting with skin signs. This book guides the reader to recognize such emergencies, helps to approach the initial phase of management, identifies the investigations, thus leading to a holistic management of the scene. Case scenarios are used in all chapters with logical flow of text, flowcharts, algorithms and representative clinical and laboratory images for better understanding of the readers. Key Features Details all dermatological emergencies Discusses manifestation of these emergencies with unique algorithms and flowcharts Examines case scenarios for first-hand experience Consists of Do's and Don'ts for effective management of cases Uses high quality clinical images for clarity
Rodent Malaria
Rodent Malaria reviews significant findings concerning malaria parasites of rodents, including their taxonomy, zoogeography, and evolution, along with life cycles and morphology; genetics and biochemistry; and concomitant infections. This volume is organized into eight chapters and begins by sketching out the history of the discovery of rodent as well as aspects of parasitology, immunology, and chemotherapy. These concepts are investigated two decades following Ignace Vincke's major discovery and Meir Yoeli's successful establishment of the method of cyclical transmission of the parasite. The following chapters focus on the taxonomy and systematics of the subgenus Vinckeia, with reference to...
Ketamine for Treatment-Resistant Depression
This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and c...
Internet and Smartphone Use-Related Addiction Health Problems
This Special Issue presents some of the main emerging research on technological topics of health and education approaches to Internet use-related problems, before and during the beginning of coronavirus disease 2019 (COVID-19). The objective is to provide an overview to facilitate a comprehensive and practical approach to these new trends to promote research, interventions, education, and prevention. It contains 40 papers, four reviews and thirty-five empirical papers and an editorial introducing everything in a rapid review format. Overall, the empirical ones are of a relational type, associating specific behavioral addictive problems with individual factors, and a few with contextual facto...
Ophthalmology and the Ageing Society
The ageing of the world’s population is one of the major achievements of modern society. By 2050, an estimated 2 billion people will be aged 60 years or over. However, ageing poses major challenges and this is especially true for the field of ophthalmology, given that the major eye diseases – age-related macular degeneration, glaucoma, and cataract – predominantly affect the elderly. The challenges facing ophthalmology in an ageing society have not previously been addressed in a comprehensive way, although there are common denominators of the various eye diseases that affect the elderly. This book provides such a comprehensive overview encompassing epidemiology, risk factors, current treatment and prophylaxis, disability, co-morbidity, and the impact on quality of life. World leaders in their respective fields provide state-of-the-art knowledge on the geriatric aspects of ophthalmology that will help to improve the management of this growing patient population.
Precision Public Health
Precision Public Health is a new and rapidly evolving field, that examines the application of new technologies to public health policy and practice. It draws on a broad range of disciplines including genomics, spatial data, data linkage, epidemiology, health informatics, big data, predictive analytics and communications. The hope is that these new technologies will strengthen preventive health, improve access to health care, and reach disadvantaged populations in all areas of the world. But what are the downsides and what are the risks, and how can we ensure the benefits flow to those population groups most in need, rather than simply to those individuals who can afford to pay? This is the first collection of theoretical frameworks, analyses of empirical data, and case studies to be assembled on this topic, published to stimulate debate and promote collaborative work.
Conservation Biogeography
CONSERVATION BIOGEOGRAPHY The Earth’s ecosystems are in the midst of an unprecedented period of change as a result of human action. Many habitats have been completely destroyed or divided into tiny fragments, others have been transformed through the introduction of new species, or the extinction of native plants and animals, while anthropogenic climate change now threatens to completely redraw the geographic map of life on this planet. The urgent need to understand and prescribe solutions to this complicated and interlinked set of pressing conservation issues has lead to the transformation of the venerable academic discipline of biogeography – the study of the geographic distribution of animals and plants. The newly emerged sub-discipline of conservation biogeography uses the conceptual tools and methods of biogeography to address real world conservation problems and to provide predictions about the fate of key species and ecosystems over the next century. This book provides the first comprehensive review of the field in a series of closely interlinked chapters addressing the central issues within this exciting and important subject.
