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Genome Editing Tools and Gene Drives
Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles and applications – as well as the advantages and disadvantages – of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students ...
Genome Editing Tools and Gene Drives
Genome editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles, and applications - as well as the advantages and disadvantages - of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and...
The Human Genome in Health and Disease
The human genome is a linear sequence of roughly 3 billion bases and information regarding this genome is accumulating at an astonishing rate. Inspired by these advances, The Human Genome in Health and Disease: A Story of Four Letters explores the intimate link between sequence information and biological function. A range of sequence-based functional units of the genome are discussed and illustrated with inherited disorders and cancer. In addition, the book considers valuable medical applications related to human genome sequencing, such as gene therapy methods and the identification of causative mutations in rare genetic disorders. The primary audiences of the book are students of genetics, ...
Genomes 4
Genomes 4 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with Genomes 3, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals including humans and other hominids. Genome sequencing and assembly methods have been thoroughly revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge ga...
A Beginner’s Guide to Using Open Access Data
Open Access Data is emerging as a source for cutting edge scholarship. This concise book provides guidance from generating a research idea to publishing results. Both young researchers and well-established scholars can use this book to upgrade their skills with respect to emerging data sources, analysis, and even post-publishing promotion. At the end of each chapter, a tutorial simulates a real example, allowing readers to apply what they learned about accessing open data, and analyzing this data to reach the results. This book can be of use by established researchers analyzing data, publishing, and actively promoting ongoing and research. Key selling features: Describes the steps, from A-Z, for doing open data research Includes interactive tutorials following each chapter Provides guidelines for readers so that they can use their own accessed open data Reviews recent software and websites promoting and enabling open data research Supplements websites which update recent open data sources
Genome Annotation
The success of individualized medicine, advanced crops, and new and sustainable energy sources requires thoroughly annotated genomic information and the integration of this information into a coherent model. A thorough overview of this field, Genome Annotation explores automated genome analysis and annotation from its origins to the challenges of next-generation sequencing data analysis. The book initially takes you through the last 16 years since the sequencing of the first complete microbial genome. It explains how current analysis strategies were developed, including sequencing strategies, statistical models, and early annotation systems. The authors then present visualization techniques ...
Pocket Guide to Mycological Diagnosis
The Pocket Guide to Mycological Diagnosis provides useful and concise information for microbiologists and professionals diagnosing the most medically relevant fungal species. Cellular and molecular techniques, immunological methods, and more accurate microscopy equipment available in most mycology laboratories now make diagnosis more routine. Furthermore, information regarding medical mycology, including identification of specific fungal pathogens, is widely available. This book helps mycologists address the emerging challenges of diagnosis. Key Features Succinct summary of fungal disease diagnosis Includes opportunistic fungal infections that can afflict immunocompromised patients Permits the identification of common fungal pathogens Reviews antifungal drugs Related Titles Ghannoum, M. A. & John R. Perfect, eds. Antifungal Therapy, 2nd ed. (ISBN 978-1-4987-6814-6) Miyaji, M., ed. Animal Models in Medical Mycology (ISBN 978-1-3158-9059-3) Razzaghi-Abyaneh, M., M. Shams-Ghahfarokhi and M. Rai, eds. Medical Mycology: Current Trends and Future Prospects (ISBN 978-1-4987-1421-1)
A Guide to Bioethics
Solving intractable biotechnological questions of evolution, medicine, and genetics is now easier due to methods permitting the rapid analysis of molecular sequence data. These advances have exposed ethical and policy concerns. How would genomic information be used and by whom? Should individuals be able to make decisions regarding their own genomic data? How accurate are these genetic tests and how should they be regulated? These and other ethical conundrums are the subject of this book. Bioethicists, biomedical policy experts and lawyers, physicians, nursing and allied health students as well as science educators will find this book helpful and engaging in exploring the complexities of modern evolutionary, genetic and biomedical data.
Genomics and Bioinformatics
A hands-on introduction to Unix, Perl and other bioinformatics tools using relevant and interesting molecular biology problems.
A Guide to AIDS
The Guide to AIDS is succinct review of HIV/AIDS from a human-interest perspective. Chapters focus on some of the common patterns and prevention of HIV transmission and debunks misconceptions about HIV and AIDS. Brief descriptions the human immune system and epidemiology of HIV are included. The cultural component of disease, treatment and living with AIDS is central to much of this guide intended to synthesize, explain and de-mystify HIV and AIDS. key selling featurws: Provides a simplified brief review of HIV and the disease it causes - AIDS Debunks myths associated with HIV transmision such as through mosquito bites Identifies simple and low cost ways to prevent the transmission and spread of HIV Illustrates the crucial role that culture plays in the prevention of HIV spread and AIDS treatment Puts a human face on the problem of diagnosing and living with AIDS
