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Human B Cell Populations
B cells used to be considered as a homogeneous population of cells destined to produce antibodies of increasing affinity and to maintain an immunological memory. In recent years, it has been determined that B cells can be subdivided into different subsets characterized by distinct morphologic, phenotypic, and functional features. Presenting results of research work on the definition of B cell subset populations, this book explains the basic mechanisms that control B cell activation, stimulation and regulation. Articles include studies on both normal and malignant B cells and describe the mechanisms underlying T-B cell interactions during the immune response. The most important advances in the field of immunodeficiency are also reported. This volume will be essential not only for basic and clinical immunologists, but also for hematologists, pathologists and rheumatologists with a special interest in the pathogenesis of lymphoproliferative or autoimmune disorders.
Chronic Lymphocytic Leukemia
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient.
Mechanisms of B Cell Neoplasia 1998
Workshops on the mechanisms of B cell neoplasia have been organized alternatively in Bethesda and Basel since 1983. Prog ress in our understanding of the development and responses of B lymphocytes is presented and discussed with the aim and hope to understand what might go wrong when B lymphocytes are transformed into malignant cells. Such knowledge might lead to better diagnosis, prevention and even cure of these terri ble diseases. The presentations at the Bethesda workshops are published as papers in volumes of Current Topics in Microbiol ogy and Immunology, while the presentations and discussions in Basel were transcribed and published in Editions Roche. For the first time, a Basel works...
Chronic Lymphocytic Leukemia
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient.
French Studies in the Philosophy of Science
Having examined previous volumes of the Boston Studies series devoted to different countries, and having discussed the best way to present contemporary research in France, we have arrived at a careful selection of 15 participants, including the organizers. Our aim is to bring together philosophers and practicing scientist from the major institutions of the country, both universities and research centers. The areas of research represented here cover a wide spectrum of sciences, from mathematics and physics to the life sciences, as well as linguistics and economics. This selection is a showcase of French philosophy of science, illustrating the different methods employed: logico-linguistic analysis, rational reconstruction and historical inquiry. These participants have the ability to relate their research both to the French tradition and current discussions on the international scene. Also included is a substantial historical introduction, explaining the development of philosophy of science in France, the various schools of thought and methods as well as the major concepts and their significance.
Chronic Lymphocytic Leukemia
Written by authors from the world's most prominent cancer centers, Chronic Lymphocytic Leukemia supplies a comprehensive, up-to-date picture of CLL and how to better treat patients inflicted with the disease.New information on developments in the molecular pathogenesis of this disease impacts how physicians approach and treat patients with CLL. The various predisposing factors for the disease are addressed along with current and future treatment modalities and recommended standards of care.
Multiple Myeloma and Related Disorders
During the past decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals. Much of this has come about as new technologies have made it possible to refine studies on chromosomes and genes and to gain information abo
Disease Markers in Exhaled Breath
With nearly 1700 references, Disease Markers in Exhaled Breath is essential reading for pulmonologists; anesthesiologists; physiologists; chest, pulmonary, thoracic, and cardiovascular physicians and surgeons; asthmologists; and upper-level undergraduate, graduate, and medical school students in these disciplines. It discusses the potential diagnos
A Warm Blanket
Alicia A. Mercer, or Tish, as she was known, was a labor negotiator with Greyhound Bus Company during one of the largest strikes in their history. She worked diligently with the Harold Washington Campaign and later became a big part of his transition team. When Tish Mercer entered a room, corporate America listened. A Warm Blanket, Celebration of Life is the loving memoir of her life written by her sister, Pamela Mercer. This inspiring memoir also includes loving remembrances for many of her friends. Tish worked as the human resources director of the Chicago Housing Authority and in global operations at ATM Global Resources. She had an impact on so many people, helping to move them into not ...
Advances in Cancer Research
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. - New Paradigms for the Treatment of Cancer: The Role of Anti-aiogenesis Agents - The Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell Differentiation - Clinical Targets for Anti-metastasis Therapy - Animal Models of Melanoma: Recent Advances and Future Prospects - The Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell Neoplasms - Epstein-Barr Virus Latency: LMP2, a Regulator or Means for Epstein-Barr Birus - Biochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointenstinal Neoplasia - Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relation to the Immune System
