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In the last decade, the clinical management of melanoma has become more effective: basic clinical studies, randomized clinical trials, and new drugs have greatly improved the prognosis of patients, both in the initial and in the advanced stage of the disease. This book offers a wide and up-to-date overview of the multidisciplinary treatment of melanoma. Among the topics discussed, there are the role of sentinel lymph node biopsy and the radical dissection, following the results of international randomized clinical trials, in particular MSLT-II. The last chapters are focused on new medical treatments in adjuvant, neoadjuvant, and metastatic settings. The volume has been written for all the professionals involved in melanoma treatment, such as general surgeons, surgical oncologists, medical oncologists, dermatologists, radiotherapists, and nuclear medicine physicians.
This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and cli...
The use of drugs as remedies for various types of diseases has a long tradition; however, it has only been recently recognized that the value of any given compound must be evaluated in light of its benefit to risk ratio. When prescribing drugs, physicians must look at the big picture of the drug's benefits in relation to its side effects and possib
Escóndete, tápate los oídos, cierra los ojos. La noche pertenece a las devoradoras de almas. Las devoradoras de almas pueden ser cautivadoras y a su vez peligrosas. Alys lo sabe bien porque vive en un mundo de adultos que se refugian detrás de altos muros y estrictas normas, a causa del terror que les infunden estas criaturas. Pero Alys tiene un vínculo con las devoradoras de almas... y con La Bestia del bosque. Y esconde una verdad sobre sí misma que no puede revelar a nadie. Cuando la amenaza se hace insoportable, Alys emprenderá un viaje a través del bosque lleno de peligros. Pero el mayor riesgo no se halla en el exterior; lo que aterroriza a Alys es el secreto sobre quién es... y sobre qué es.
Padre Pio da Pietrelcina fu uno straordinario taumaturgo, cioè un operatore di prodigi, caratteristica legata alla santità che non sempre si verifica, ma che quando è presente affascina in maniera irresistibile. E in Padre Pio questa caratteristica era espressa all'ennesima potenza. Nel mondo cattolico è conosciuto per le stimmate, per le bilocazioni, per i misteriosi profumi che emanavano dalla sua persona. Ma soprattutto per i miracoli ottenuti per sua intercessione, dopo la morte. Questo ebook ne raccoglie una piccola parte, raccontati dai diretti protagonisti. Cantanti e attori famosi, persone comuni, religiosi, docenti, artisti: testimoni diretti di un mistero che rappresenta la conferma di una presenza.
Comprehensive Coordination Chemistry II (CCC II) is the sequel to what has become a classic in the field, Comprehensive Coordination Chemistry, published in 1987. CCC II builds on the first and surveys new developments authoritatively in over 200 newly comissioned chapters, with an emphasis on current trends in biology, materials science and other areas of contemporary scientific interest.
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