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Melatonin
Melatonin: Biosynthesis, Physiological Effects, and Clinical Applications provides a thorough review of recent advances in major areas of melatonin research. The book is arranged in a logical sequence, beginning with the history of melatonin and then proceeding to cover its biochemistry and secretion, physiological effects, and clinical significance. New findings and current concepts are emphasized, and a significant amount of previously unpublished data are included. The book will be an important reference for neurobiologists, cell biologists, ophthalmologists, endocrinologists, neuroendocrinologists, reproductive biologists, psychiatrists, and other researchers and clinicians interested in melatonin.
Alcoholism: A Molecular Perspective
This book contains selected proceedings from the NATO Advanced Study Institute (AS I) "The Molecular Pathology of Alcoholism" held at the Hotel Il Ciocco in Tuscany during 26th August - 6th September 1990. Alcoholism remains one of the most challenging problems in medical care, with far-reaching medical, social and economic consequences. For example in the U. S. , estimates indicate that 18 million people have a serious drinking problem and that the total cost to the economy of alcohol abuse is $117 billion. Treatment of alcohol dependence and other alcohol-related disorders accounts for almost 15% of the total health bill of the United States. Despite the scale of the medical problem, biome...
Vascular Endothelium
This monograph contains the proceedings from the Advanced Study Institute on "Vascular Endothelium: Physiological Basis of Clinical Problems" which took place in Corfu, Greece in June 1990. The meeting consisted of twenty-eight lectures, most of them adapted as full length papers in this volume, as well as numerous short oral and poster communications which are abstracted and also included in alphabetical order (pages 239-302). There were ninety-six participants from ten NATO and four other European countries. The meeting was the second in as many years dealing with a specific subject in Endothelial Cell biology. Following the 1988 discussion on "Receptors and Transduction Mechanisms", the p...
Bioorganic Chemistry in Healthcare and Technology
In current thinking, Bioorganic Chemistry may be defined as the area of chemistry which lies in the border region between organic chemistry and biology and which describes and analyzes biological phenomena in terms of detailed molecular structures and molecular mechanisms. This molecular-level view of biological processes is not only essential to their fuller understanding but also serves as the platform for the application of the principles of such processes to areas of health care and technology. The objective of the ASI workshop on " Bioorganic Chemistry in Healthcare and Technology", held in the Hengelhoef Congress Centre in Houthalen-Helchteren, Belgium, from September 18-21, 1990, was ...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Organization of the Early Vertebrate Embryo
This book is the product of a NATO Advanced Study Institute of the same name, held at the Anargyrios and Korgialenios School on the island of Spetsai, Greece, in September 1994. The institute considered the molecular mechanisms which generate the body plan during vertebrate embryogenesis. The main topics discussed included: commitment and imprinting during germ cell differentiation; hierarchies of inductive cell interactions; the molecular functioning of Spemann's organizer and formation of embryonic axes; the extracellular matrix and the cytoskeleton in relation to morphogenesis and cell migration; neurogenesis and patterning of the neuraxis; the regulation of pattern formation by Hox genes...
Light and Biological Rhythms in Man
In this volume, current knowledge on light as a regulator of biological rhythms is considered from both basic science and clinical perspectives. Chapters by leading experts cover the whole range of biological rhythms, from infradian and circadian to the longer ultradian rhythms, in a wide variety of mammalian species. The chapters on humans provide a basis on which to establish mechanisms for mediating the therapeutic and physiologically beneficial effects of light as a regulator of rhythms in health and disease.
Obesity Treatment
Treatment outcome has certainly improved since Stunkard and McLaren-Hume (1959) reviewed the literature and found that less than 25% of obese patients lost 20 pounds or more and less than 5% lost 40 pounds or more. However, one of the few points on which almost all obesity researchers agree is that to date, our results are quite modest and we are generally unsuccessful in promoting effective weight maintenance among obese persons. As the title of a more recent article, "Improving long-term weight loss: Pushing the limits of treatment," (Brownell & Jeffrey, 1987, [emphasis added]) suggests, many believe that we have pushed our current treatment paradigms to the limit. It was with this backgro...
Developmental Patterning of the Vertebrate Limb
Following pioneering work by Harrison on amphibian limbs in the 1920s and by Saunders (1948) on the apical ridge in chick limbs, limb development became a classical model system for investigating such fundamental developmental issues as tissue interactions and induction, and the control of pattern formation. Earlier international conferences, at Grenoble 1972, Glasgow 1976,and Storrs, Connecticut 1982, reflected the interests and technology of their time. Grenoble was concerned with ectoderm-mesenchyme interaction, but by the time of the Glasgow meeting, the zone of polarizing activity (ZPA) and its role in control of patterning was the dominant theme. Storrs produced the first intimations t...
