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Basophils and Mast Cells
This second edition provides updated and new chapters to build on and extend the strengths of the first edition. Chapters guide readers through basic biology of basophils, obtaining the cells by purification, culture of stem cells progenitors, peripheral CD34+ stem cell-derived mast cells, basophils from CD34+ progenitors, diagnostic applications, gene expression patterns in basophils, roles of basophils in different asthma phenotypes, knockout, and disease models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Basophils and Mast Cells: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Clinical Applications of Immunomics
Innate immunity is one the most evolutionally conserved systems, designed to protect the organism from viruses and bacterial infections, stress and many other types of attacks from the outside world. During the past decade, the capacity of molecular biology and information technology to produce and analyse data have grown exponentially, rapidly reforming many aspects of immunology research in the post-genomics era. As a result, scientific understanding of signalling networks governing the innate immunity response in human tissues and other organisms has evolved beyond recognition, compared to even just a decade ago. Many strategies have been designed over the years to identify novel proteins...
Biophysical Methods for Diagnosing Human Tissue Anomalies
Medical diagnosis of tissue anomalies, particularly cancer, is often limited by the constraints of current imaging technologies. This book introduces two approaches to address this issue: the imaging and the non-imaging methods. In the imaging category, the book unveils a pioneering technique based on radio tomosynthesis. Initially proven effective in detecting breast anomalies, this imaging method is now under evaluation for its potential in identifying brain anomalies. For non-imaging diagnostics, it delves into Fourier-transform infrared spectroscopy (FTIR), a technique known for its speed and reliability. The book demonstrates its successful application in diagnosing a range of cancers, including oral, uterine, ovarian, gastrointestinal, colorectal, and skin cancers. Furthermore, it explores its utility in predicting embryo quality and assessing pressure injuries. To augment these methods, the book employs machine learning algorithms, evaluating their efficacy in creating discriminative models for tissue anomalies.
The Routledge Handbook of Critical Resource Geography
resource-exploitation dynamics are emphasized a single comprehensive volume that provides a systematic and rigorous overview of state-of-the-art critical-geographical scholarship on resources contributions from leading voices and emerging researchers who draw on diverse theoretical and methodological traditions and whose expertise spans a wide variety of resource sectors and world regions
Animal Lectins
Introduces Groundbreaking Approaches for Assessing Lectin Function Lectins and their ligands are under quite a heavy microscope due to their potential applications to pharmacology, immunology, cancer therapy, and agriculture. With growing interest in the glycobiology field, the body of research related to lectin roles has grown at an explosive rate
Insights in Molecular Innate Immunity: 2022
We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Immunology. Frontiers has organized a series of Research Topics to highlight the latest advancements in research across the field of Immunology in 2022. This editorial initiative of particular relevance, led by Prof. Francesca Granucci Specialty Chief Editor of the Molecular Innate Immunity section, and Dr. Uday Kishore is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of molecular innate immunity.
Biology of Parasitism
Biology of Parasitism is based on the Biology of Parasitism Course at the Marine Biological Laboratory in Woods Hole, Massachusetts. Having just celebrated its 20th offering, this Course has distinguished itself as the premier, world-renowned training ground for future generations of parasitologists. The primary goal of the Course is to attract and introduce the very best and most promising young researchers to the many unresolved problems in parasitology and prepare them for their future as independent investigators in the field. The rigorous program combines state-of-the-art laboratory research with a program of visiting lecturers who bring together the most current research in the field. ...
Nanoscale Biophysics of the Cell
Macroscopic cellular structures and functions are generally investigated using biological and biochemical approaches. But these methods are no longer adequate when one needs to penetrate deep into the small-scale structures and understand their functions. The cell is found to hold various physical structures, molecular machines, and processes that require physical and mathematical approaches to understand and indeed manipulate them. Disorders in general cellular compartments, perturbations in single molecular structures, drug distribution therein, and target specific drug-binding, etc. are mostly physical phenomena. This book will show how biophysics has revolutionized our way of addressing the science and technology of nanoscale structures of cells, and also describes the potential for manipulating the events that occur in them.
Vitamin B12
Cobalamin (vitamin B12) was discovered in the first half of the 20th century. Vast amount of information on the role of the vitamins in human health and disease became available. Cobalamin science was, however, based on theoretical concepts that have been accepted without further proof of facts and hypotheses. Recently, the breath-taking pace of development in research technologies has changed our understanding for the role of nutrients and the complex interaction between diet, environment and diseases. Conditions like aging, diet and drugs increase the risk of developing cobalamin deficiency, probably because of diminished ability to liberate, absorb or distribute the food-derived vitamin. ...
