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In the 1970s, Dr. Alan Scott sought to selectively weaken eye muscles to treat strabismus (when one or both eyes are misaligned) without surgery. After failed attempts with other agents, Scott developed a method to stabilize the bacteria that causes botulism, culminating in a drug that eventually became known as Botox. In Death to Beauty, Eugene M. Helveston, MD, follows the unlikely story of botulism's 1817 discovery in contaminated German sausages, to its use in military and research facilities, to Scott, an ophthalmologist who aimed to safely use the drug in humans. Scott struggled alone as an unknown in the pharmaceutical industry, searching for clinical trial financing and FDA approval,...
The exceptionally successful history of botulinum toxin and its likely future has hardly an equivalent. Initially, it was used in strabismus, blepharospasm and hemifacial spasm, later also in focal dystonia and spasticity and it has been shown to effectively treat wrinkles, hyperhidrosis and a great number of ensuing indications. By treating symptoms or disorders associated with pain, its analgesic effect was first noticed. The efficacy and reasons for this side effect have since been investigated and a number of models explaining the mode of action have been presented. However, even if we know that botulinum toxin undoubtedly helps in certain pain syndromes, there is still much work to do to identify the major ones, define the optimum dose and the preferred site of injection. Indicating current positions and kindling the growing interest in this extraordinary therapeutic agent this book presents a timely overview on pain management with botulinum toxin. Thus, it will be of great interest especially for anesthesiologists and neurologists in their clinical work and medical research.
Comprehensive reference for neurologists, neurosurgeons and physical therapists on the treatment of all dystonias in children and adults.
Bei einem Notfall steht der Arzt unter besonderem Druck. Da ist es wichtig für ihn, schnell auf Fakten und konkrete Handlungsanweisungen zugreifen zu können. Der Notarzt-Leitfaden bietet dieses Wissen.Alle Krankheitsbilder systematisch dargestellt - von der Symptomatik, über Sofortdiagnostik bis zu den Prinzipien der WeiterbehandlungInkl. Pädiatrie, Gynäkologie, Geburtshilfe, Psychiatrie, Ophthalmologie, HNO, DermatologieMit Differenzialdiagnosetabellen für den schnellen ÜberblickHilfreiche Tipps, z.B. venöse ZugangstechnikenNicht alltägliche Rettungssituationen, wie z.B. Großschadensfall, Chemieunfall, Terroranschlag Neu in der komplett überarbeiteten und aktualisierten 8. Auflage:Einarbeitung der aktuellen ReanimationsrichtlinienTraumatologie stark überarbeitetNeue Sprache im Fremdsprachenführer: Arabisch. Die ideale Ergänzung zu den bisherigen Sprachen englisch, italienisch, polnisch, russisch u.v.m.
In this publication a comprehensive overview on the pathophysiology and treatment of hyperhidrosis with a focus on the new therapy with botulinum toxin is given by renowned experts from Europe and the USA. In the first part the pathophysiology of hyperhidrosis, rare forms of sweating and their symptoms, as well as the different topical and surgical treatments for focal hyperhidrosis are discussed. The second part deals with botulinum toxin. Besides a historic survey of the drug the reader is introduced to the pharmacological particularities and the different modalities of treatment for focal hyperhidrosis. Complications and side effects of the therapy are presented as well. The final chapter is reserved for other dermatological indications like anal fissure and wrinkles.
Providing practical, visually oriented guidance on the benefits of botulinum toxin in a wide variety of disorders, some new and unexpected, this new edition of Manual of Botulinum Toxin Therapy is fully updated in scope and detail. Chapters discuss the pathophysiology of each condition, summarizing the rationale for botulinum toxin, and describing the injection approach. Clear illustrations of the injection sites are included, using a 'clinician's eye' perspective, which allows physicians to readily identify anatomical landmarks and approach angles for injection. Dosing tables for available toxin formulations are included. The Manual covers cosmetic treatment of the upper and lower face, as well as aesthetic smile correction. Extensive guidance on how to use ultrasound and how cadaveric dissections can assist localization and targeting of injections is provided. Designed for teaching and bedside guidance, the Manual is useful to a diverse range of clinicians looking to use botulinum toxin in their practice.
'Highly persuasive ... a well-organised and solid dossier that alerts us to legalised chemical trickery' Joanna Blythman, The Spectator 'A bombshell book' Daily Mail 'Eye-opening and important . . . a book full of righteous anger' Bee Wilson, from her Foreword Did you know that bacon, ham, hot dogs and salami are classified by the World Health Organization (WHO) as 'category 1 carcinogens'? Would you eat them if you knew they caused bowel cancer? Following ten years of detailed investigation, documentary film-maker Guillaume Coudray presents a powerful examination of the use of nitro-additives in meat. As he reveals, most mass-produced processed meats, and now even many 'artisanal' products,...
The third part of Neurological Disorders in Famous Artists presents painters, musicians, and writers who had to fight against an acute or chronic neurological disease. Sometimes this fight was without success (e.g. Shostakovich, Schumann, Wolf, Pascal), but often a dynamic and paradoxical creativity of the clinical disorder was integrated into their artistic production (e.g. Klee, Ramuz). Occasionally, some even wrote the first report of a medical condition they observed in themselves, like Stendhal who made a detailed report of aphasic transient ischemic attacks before dying of stroke shortly thereafter. In rarer instances, a neurological disease was inaccurately attributed to an artist in order to explain certain features of his work (de Chirico, Schiele). Some chapters in this publication focus on neurological conditions reported in artistic work, including descriptions by Shakespeare and Dumas. Bringing new light to both artists and neurological conditions, this book serves as a valuable and entertaining read for neurologists, psychiatrists, physicians, and anybody interested in arts, literature and music.
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Die Endlichkeit des Lebens ruft Unbehagen und Ängste hervor. Statt die Augen vor dem Unausweichlichem zu verschließen, möchte das Buch der Theologin Larissa C. Seelbach alltagsrelevantes Handlungs- und Einordnungswissen bieten. Das Buch führt sachlich an das Thema "Lebensende" heran und gibt einen facettenreichen Überblick über die Erkenntnisse von Sterbeforschung, Medizin, Soziologie und Bestattungswesen. Erfahrungsberichte Betroffener werden referiert und ermöglichen so auch einen emotionalen Zugang. Die Bedeutung der christlichen Hoffnung angesichts von Sterben und Tod wird in einem eigenen Kapitel erörtert.