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Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neuro...
Contains the first printing of Sartor resartus, as well as other works by Thomas Carlyle.
Explore Edinburgh’s secret history through a fascinating selection of stories, facts and photographs.
Since 1940, when an Australian legation was established in Washington DC, Australian governments have expected much from their representatives in the American capital. This book brings together expert analyses of those who have served as heads of mission and of the challenges they have faced. Ranging beyond conventional studies of the Australian–United States relationship, it provides insights into the dynamics between Australian and US policymakers and into the culture of one of Australia’s oldest and most important overseas missions. It provides an appreciation of the importance of the embassy and the head of mission in Washington in mediating the relationship between Australia and the United States and of their role in managing expectations in Canberra and Washington. Australia Goes to Washington also sheds new light on personal trials and achievements at the coalface of Australian–United States relations.
1h The 5 International Conference on the Progress in Alzheimer's Disease and Parkinson's 51 1 Disease took place from March 31 to April 5 \ 2001 in Kroto, Japan. This international 1 conference was organized as a joint Congress with the 9 International Catecholamine Symposium. A total of 1258 clinicians and researchers participated in this joint congress 1h from 38 countries in the world. This book represents the proceedings of the 5 Conference on Alzheimer's and Parkinson's disease. The International Conference on the Progress in Alzheimer's and Parkinson's disease was first launched by Professor Abraham Fisher of Israel and Professor Israel Hanin of USA. The first conference was held in Ei...
This fascinating selection of photographs traces some of the many ways in which Haddington has changed and developed over the last century.