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Regulation of Human Cancer by Cytokines
This book considers clinical problems associated with new modalities of cancer treatment involving recombinant cytokines. The first half of the book is devoted to various types of associations of cytokines with tumor cells, while the second half addresses the therapeutic potential of multidisciplinary devices in biological treatment with recombinant cytokine. Some of these indicate the future direction of cancer treatment.
Bone Marrow Transplantation
In the last decade, remarkable advances have been made in bone marrow transplantation (BMT), which is now becoming a powerful tool in the treatment of diseases such as leukemia, aplastic anemia, and congenital immunodeficiency. In animal experiments, it has been found that BMT can be used to treat not only systemic autoimmune diseases but also organ-specific autoimmune diseases. In humans, it has recently been shown that rheumatoid arthritis, ulcerative colitis, and Crohn's disease can be successfully treated after BMT. This volume contains new information on how to prevent graft rejection, how T cell functions can be completely restored, and how concomitant BMT can prevent the rejection of organ allografts without the use of immunosuppressive agents. BMT will become an increasingly useful and powerful treatment for various currently intractable diseases, and this book will contribute by providing details of the latest research in the field.
Recent Advances and Future Directions in Bone Marrow Transplantation
Siegmund J. Baum It has become a tradition to commence advocated by Leonard Cole) (3). important meetings of this society with At about the same time, Alpen and reminiscence and nostalgia. Bone marrow Baum (4), using a larger mammal, the dog, transplantation, which has a history of only demonstrated that injecting autologous marrow 30 to 40 years, permits this process, since post irradiation would protect lethally some of the early investigators are still with irradiated animals (see Table). Certainly, us. For example, over the past 15 years, we protection was obtained from the cellular have had three symposia in honor of Egon constituents of the bone marrow. Lorenz. As we all know, the team of Lorenz, We undertook to test on dogs the Uphoff and Congdon was involved in the first hypothesis of Gengozian and Makinodum (5) that successful transplantation of syngeneic and increasing the radiation dose will increase allogeneic bone marrow into irradiated immunologic tolerance for allogeneic implants.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Myelodysplastic Syndrome and Cytokines
Myelodysplastic syndrome (MDS) is thought to be an incurable disease typified by a clonal disorder in the maturation and proliferation stage of multipotential hematopoietic stem cells. The three main themes in this book are: Influence of cytokines on the maturation and proliferation of normal hematopoietic progenitor cells as well as leukemic cells including those from patients with MDS. Synergisms of cytokines in vitro and in vivo. Clinical features of MDS including BMT. The book provides useful information regarding effective treatments of MDS based on a better understanding of the cytokine actions as well as the association with the hematopoiesis including the network system.
The Mechanism and New Approach on Drug Resistance of Cancer Cells
Therapeutic approaches targetting drug resistance mechanisms have been studied in the clinical field of cancer chemotherapy, and this text contributes to the progress in clinical research on the circumvention of drug resistance.
