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Sarkozy came to power promising radical political and social change while simultaneously developing a presidential persona that melded the public and the personal under the glare of media attention, unparalleled in the French Fifth Republic. This volume provides a detailed analysis of the fit between his ambitions and the outcomes of his presidency
In this incisive, acerbic work, Alain Badiou looks beyond the petty vulgarity of the French president to decipher the true significance of what he represents—a reactionary tradition that goes back more than a hundred years. To escape the malaise that has enveloped the Left since Sarkozy’s election, Badiou casts aside the slavish worship of electoral democracy and maps out a communist hypothesis that lays the basis for an emancipatory politics of the twenty-first century.
Numbers, Information and Complexity is a collection of about 50 articles in honour of Rudolf Ahlswede. His main areas of research are represented in the three sections, `Numbers and Combinations', `Information Theory (Channels and Networks, Combinatorial and Algebraic Coding, Cryptology, with the related fields Data Compression, Entropy Theory, Symbolic Dynamics, Probability and Statistics)', and `Complexity'. Special attention was paid to the interplay between the fields. Surveys on topics of current interest are included as well as new research results. The book features surveys on Combinatorics about topics such as intersection theorems, which are not yet covered in textbooks, several contributions by leading experts in data compression, and relations to Natural Sciences are discussed.
This book constitutes the refereed proceedings of the 7th International Workshop on Probabilistic Graphical Models, PGM 2014, held in Utrecht, The Netherlands, in September 2014. The 38 revised full papers presented in this book were carefully reviewed and selected from 44 submissions. The papers cover all aspects of graphical models for probabilistic reasoning, decision making, and learning.
Gene silencing is a general term describing epigenetic processes of gene regulation. The term gene silencing is generally used to describe the 'switching off' of a gene by a mechanism other than genetic mutation. That is, a gene which would be expressed (turned on) under normal circumstances, is switched off by machinery in the cell. Genes are regulated at either the transcriptional or post-transcriptional level. Transcriptional gene silencing is the result of histone modifications, creating an environment of heterochromatin around a gene that makes it inaccessible to transcriptional machinery (RNA polymerase, transcription factors, etc.). Post-transcriptional gene silencing is the result of mRNA of a particular gene being destroyed. The destruction of the mRNA prevents translation to form an active gene product (in most cases, a protein). A common mechanism of post-transcriptional gene silencing is RNAi. Both transcriptional and post-transcriptional gene silencing are used to regulate endogenous genes. This book presents the latest research in this important field.
Taking the reader from an understanding of the basic mechanisms of heart failure through to an appreciation of the complexities of heart failure management and the remarkable improvements possible with good treatment, the Oxford Textbook of Heart Failure 2e covers all aspects necessary to manage a patient with heart failure. In full colour throughout, containing over 300 illustrations, and supported by detailed referencing from the huge evidence base that has developed over the last two decades, the textbook also includes extensive chapters on common co-morbidities. The new edition has been completely updated in line with new British and European Guidelines and contains new chapters on; Natriuretic Peptides and Novel Biomarkers in Heart Failure, The Future of Heart Failure, and Regenerative Therapies. Essential reading for consultant cardiologists and those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses.
In this issue of Heart Failure Clinics, Guest Editors Giuseppe Limongelli and Eduardo Bossone bring their considerable expertise to the topic of rare cardiovascular diseases. Top experts in the field cover key topics such as coronary artery dissection, genetics in congenital heart disease, HCM in Rasopathies, and more. - Provides in-depth, clinical reviews on Rare Cardiovascular Diseases, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. - Contains 17 relevant, practice-oriented topics including The influence of genotype on the phenotype, clinical course, and risk of adverse events in children with Hypertrophic cardiomyopathy; Unravelling the genetic background in heritable and non-heritable BAV: a long roadmap; The risk of sudden unexpected cardiac death in children: epidemiology, clinical causes, and prevention; The renal involvement in patients with storage and infiltrative cardiomyopathies; and more.
Three-dimensional echocardiography is the most recent fundamental advancement in echocardiography. Since real-time 3D echocardiography became commercially available in 2002, it has rapidly been accepted in echo labs worldwide. This book covers all clinically relevant aspects of this fascinating new technology, including a comprehensive explanation of its basic principles, practical aspects of clinical application, and detailed descriptions of specific uses in the broad spectrum of clinically important heart disease. The book was written by a group of well-recognized international experts in the field, who have not only been involved in the scientific and clinical evolution of 3D echocardiogr...
This Textbook will give the reader a detailed understanding of the use of 3D echo covering a wide range of topics; from the evolution of RT3D echo to the role of RT3D echo in drug trials, including chapters on the Principles of Transthoracic and Transesophageal Real-time 3D echocardiography. Other books in this area are more varied, less specific.
This book gathers selected papers from the First International Symposium on Bioinformatics and Biomedicine. Issues related to medicine and health care constitute one of the grand challenges faces by the mankind, and this naturally implies a growing interest in these problems among both researchers and scholars, politicians and policymakers, as well as economist. The present values which gather selected papers from the First International Symposium on Bioinformatics and Biomedicine (BioInfoMed’2020) is a recent response to this interests. In the subsequent sections and chapters, it covers a multitude of various topics related to bioinformatics, biomedicine, bioenginering, as well as a broadly perceives healthcare. Issues related to decision making in bioinformatics, biomedicine and health care, mathematical modelling in biomedicine and health care, artificial intelligence in biomedicine and health care, uncertainty and imprecision, notably intuitionistic fuzzy sets with applications in bioinformatics and biomedicine, biomedical approaches and applications, biomedical imaging and image processing, and excitable structures and motor activity are covered.