Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Peroxisomes
Provides an update on several new aspects of peroxisome biology, including the role of the peroxisome proliferator activated receptor. The book covers morphilogical, biochemical and molecular biological aspects of peroxisomes.
Cellular Organelles and the Extracellular Matrix
This volume is in two parts. The first contains the remaining chapters on cellular organelles and several chapters relating to organelle disorders. An account of mitochondriopathis is given in the chapter on the mitochondrion rather than in a separate one. The subject matter of this part of the volume shows quite clearly that the interdisciplinary approach to the study of organelles has shed considerable light on the nature of the mechanisms underlying the etiology and pathobiology of many of these disorders. As an example, mutations in the genes encoding integral membrane proteins are found to lead to disturbances in peroxisome assembly. It is also interesting and significant that mistarget...
Studies in Inherited Metabolic Disease
With improved control of most environmental causes of disease, genetic illness has assumed a primary importance in the causation of handicap and mortality in all age groups. At present, effective therapy is available for relatively few genetic conditions and prenatal diagnosis is an important option for couples at high risk. The task of providing prenatal diagnosis for these couples requires a team approach between clinicians and scientists, and is complicated by the large number of diverse conditions and by the rapid developments in the field, both obstetric in relation to imaging and tissue sampling methods and genetic in relation to techniques for analysis. Against this background, the ai...
Developments in High Energy Physics
We summarize the situation regarding non-polynomial Lagrangians: I should make the qualification that an enor mous amount of verification is needed before the problems of renormalizability are all sorted out, but one may ten tatively state: 1) All matrix elements are finite for theories where the Dyson index D is less than two. 2) For the cases when D=2 or 3, counter-terms have been explicitly written which absorb all infinities and the theories are renormalizable. 3) Mixed theories of polynomial and non-polynomial fields appear to be renormalizable provided the Dyson in dices separately and jointly fulfill renormalizability criteria. We believe that weak interactions, chiral La grangians and Yang-Mills theory fall into this class though detailed proofs have not yet been constructed. 4) It seems likely that to each order in the major coupling (and to all orders in the minor coupling}the S matrix elements, as computed by methods outlined, satisfy the necessary unitarity and analyticity requirements.
Lipid Storage Disorders
This book presents the proceedings of the meeting on "Lipid Storage Disorders" which took place in Toulouse, France, in September 14-18, 1987 and which was set up as a joint NATO Advanced Research Workshop and INSERM International Symposium. The meeting probably was the first truly international symposium devoted entirely to basic as well as applied aspects of lipid metabolism as related to the lipid storage disorders. Participants came from Europe, USA, Israel and Japan, and presented data on research in molecular biology and genetics, enzymology, cell biology as well as medical and epidemiological aspects of normal and pathological lipid metabolism. In the latter case, special attention wa...
At the Frontier of Particle Physics
Introduction / M. Shifman -- Introducing Boris Ioffe / B.V. Geshkenbein -- Boris Lazarevich Ioffe is 75 / I.B. Khriplovich -- ch. 1. Pages of the past. A top secret assignment / B.L. Ioffe. Editor's comments. Snapshots from the 1950's / Yu. F. Orlov -- ch. 2. The making of QCD. Quantizing the Yang-Mills field / L.D. Faddeev. The discovery of asymptotic freedom and the emergence of QCD / D.J. Gross. Editor's note. Recollections on dimensional regularization and related topics / C.G. Bollini. Historical curiosity: how asymptotic freedom of the Yang-Mills theory could have been discovered three times before Gross, Wilczek, and politzer, but was not / M. Shifman -- ch. 3. From hadrons to nuclei:...
A Multidisciplinary Approach to Myelin Diseases II
The diseases that fall under the generalized group of demyelinating diseases -Multiple Sclerosis, Leukodystrophyes, Encephalomyelitis-are the focus of worldwide concern. This volume contains papers presented by leading scientists who attended the NATO Advanced Research Workshop held at the Istituto Superiore di SanitA, Rome, March 1-4, 1993. This book is an update of the previous one published in 1987 of the research discussed at a similar meeting held in 1986. It was decided to hold this 2nd meeting since there has been great progress in the advances in understanding the myelinogenesis process in the last five years. The workshop gathered together scientists from many fields such as cellula...
Peroxisomal Disorders and Regulation of Genes
In most peroxisomal disorders the nervous system is severely affected which explains the clinical and community burden they represent. This is the first book to focus not only on the mutations causing these inherited illnesses, but also on mechanisms that regulate, suppress or enhance expression of genes and their products (enzymes). Indeed since the success and completion of the Human Genome Project all genes (coding DNA sequences) are known. However, of many, their function, and the role of the gene product has not been determined. An example is X-linked adrenoleukodystrophy, the most frequent peroxisomal disorder. Children are born healthy, but in more than 1 out of 3, demyelination of the brain starts unpredictably and they die in a vegetative state. The gene mutated in most families has been known for 10 years; but the true role of the encoded protein, ALDp, is still speculative; and within the same family, very severe and asymptomatic clinical histories co-exist, unexplained by the mutation.
Diagnosis of human peroxisomal disorders
Peroxisomal disorders constitute a major research front in clinical genetics, paediatrics and cell biology. Since 1983, the metabolic defect in some 20 different peroxisomal disorders has been described. The best known conditions include Zellweger syndrome, rhizomelic chondrodysplasia punctata and X-linked adrenoleukodystrophy and, in the most recent edition of The Metabolic and Molecular Basis Inherited Disease, edited by Scriver and colleagues, more than 100 pages are now devoted to the subject. Progress in our understanding of these conditions, and their diagnosis, results from the application of a variety of laboratory investigations. These include microscopic studies, analysis of metabo...
