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Mitochondria in Pathogenesis
Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.
Designing an Anthropology Career
Sherylyn Briller and Amy Goldmacher's Designing an Anthropology Career: Professional Development Exercises, Second Edition provides undergraduates, graduate students and career changers with the tools they need to identify their professional goals and follow through on them. Part I establishes a framework for how to design -- or update -- a career in anthropology or related fields. The authors discuss how social science is needed now more than ever and offer ideas for how to find employment in many different realms. Part II contains a series of professional development exercises to help workbook users articulate their personal and professional histories, special abilities and career goals. Each exercise includes an example from an anthropology student or professional anthropologist as a model for completion. Doing these customizable exercises will help people turn their love of anthropology and existing knowledge and skills into meaningful and lasting careers.
The Spirit of Vatican II
Vatican II profoundly changed the outlook and the message of the Catholic Church. After decades, if not centuries, in which Catholic public opinion appeared to be primarily oriented towards the distant past and bygone societal models, suddenly the Catholic Church embraced the world as it was, and it joined in the struggle to create a radiant future. The Sixties were a time of great socio-cultural and political ferment in Europe as a whole. Especially the second half of the 1960s and the first half of the 1970s witnessed an astounding range of 'new' and 'old' social movements reaching for the sky. Catholic activists provided fuel to the fire in more ways than one. Catholics had embarked on th...
Signaling Pathways in Liver Diseases
Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.
The European Countryside during the Migration Period
Research on late antique and early medieval migrations has long acknowledged the importance of interdisciplinarity. The field is constantly nourished by new archaeological discoveries that allow for increasingly refined pictures of socio-economic development. Yet the perspectives adopted by historians and archaeologists are frequently different, and so are their conclusions. Diverging views exist in respect to varying geographical areas and scholarly traditions too. This volume brings together history and archaeology to address the impact of the inflow and outflow of migrations on the rural landscape, the creation of new settlement patterns, and the role of migrations and mobility in transforming society and economy. Such themes are often investigated under a regional or macro-regional viewpoint, resulting in too fragmented an understanding of a widespread phenomenon. Spanning Eastern and Western Europe, the book takes steps toward an integrated picture of territories normally investigated as separate entities, and critically establishes grounds for new comparisons and models on late antique and early medieval transformations.
Studies on Hepatic Disorders
This volume examines the current state of free radical biology as it impacts on hepatic disorders. It takes a thorough look at the relationship of oxidative stress in acute and chronic disease and takes into account factors like: redox biomarkers; antioxidant defense and protection; cell signaling, mutations; oxidative damage involving lipids, proteins and nucleic acids; membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function and toxicology and hypoxia. Studies on Hepatic Disorders, the latest volume in the Oxidative Stress in Basic Research and Clinical Practice series, provides a comprehensive look at liver topics. It is organized into four sect...
Signaling Pathways in Liver Diseases
Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.
