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Bulletin
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Department Bulletin
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Advances in Pharmacology and Chemotherapy
Advances in Pharmacology and Chemotherapy
The Chemistry of Antitumour Agents
Walter C. J. ROSS Emeritus Professor, University of London To paraphrase a statement made by Howard E. Skipper many years ago, 'We cancer chemotherapists have often exploited and overworked our chemist colleagues and they have been conveniently forgotten at award giving times'. This book is an attempt to rectify this and highlight the contribution of the chemist in modifying the structure of various types of agent to enhance their effectiveness as inhibitors of the growth of neoplastic tissues. Cancer chemotherapy is a relatively new discipline, coming later than the introduction of sulphonamides and antibiotics. Modern anti-cancer therapy started with the report of the use of a war gas meth...
Official Register
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Radiotherapy, Surgery, and Immunotherapy
The history of the development of cancer therapy has been marked by a recurring pattern, one of initially exciting and encouraging results as new methods were introduced, followed by dismaying failures. The extremity of the disease and its high mortality have dictated that each means of damaging tumor cells would be rapidly explored and exploited as a mode of therapy, long before the correspond ing theory and technique were completely understood and perfected. Thus radiation was used as an antitumor agent almost immediately following recogni tion of its cytodestructive capability. Equally constant, following the rapid utilization of new therapeutic methods, has been a period of significant t...
Radiation Research
Radiation Research: Biomedical, Chemical and Physical Perspectives documents the proceedings of the Fifth International Congress of Radiation Research held in Seattle, Washington, 14-20 July 1974. While the focus of the Congress was on fundamental research, there were several well-attended sessions on the practical aspects of radiation research as it relates to radiotherapy, central station power generation by both nuclear fission and fusion, and the environment. This volume contains 126 papers organized into 31 parts. Beginning with a keynote address and a lecture on the time scale in radiobiology, the subsequent contributions cover a wide range of topics presented over several sessions. Topics discussed during these sessions include energy needs, nuclear power, and the environment; prospects for fusion power; technological applications of radiation; human radiobiology; hazards of radiation exposure relative to other environmental agents; the basic physics of the interactions of radiation with matter; particle penetration phenomena; and radiation effects in frozen media.
Radiation Sensitizers
In spite of years of clinical research and trials of a variety of new and promising therapies, cancer remains as a major cause of morbidity and mortality. Use of ionizing radiation in treatment of cancer quickly followed the discovery of X-rays and radioactivity at the dawn of the last century. The limited success of radiotherapy has been attributed to several factors if which the intrinsic radioresistance of tumor cells, their fast reproduction, and tumor hypoxia are the major causes. Radiation Sensitizers: A Contemporary Audit presents data on newer hypoxic cell sensitizers like senazole and deal with old molecules such as chlorpromazine in a new role of sensitization. Bringing together information scattered throughout published and unpublished literature, the book contains contributions from an international panel that examines new therapies and new uses of old therapies. It contains tables and diagrams that illustrate the concepts and make the information easy to find.
