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In 1638, a small book of no more than 92 pages in octavo was published “appresso Gioanne Calleoni” under the title “Discourse on the State of the Jews and in particular those dwelling in the illustrious city of Venice.” It was dedicated to the Doge of Venice and his counsellors, who are labelled “lovers of Truth.” The author of the book was a certain Simone (Simḥa) Luzzatto, a native of Venice, where he lived and died, serving as rabbi for over fifty years during the course of the seventeenth century. Luzzatto’s political thesis is simple and, at the same time, temerarious, if not revolutionary: Venice can put an end to its political decline, he argues, by offering the Jews a...
Endocytosis is a fundamental cellular process by means of which cells internalize extracellular and plasma membrane cargos for recycling or degradation. It is important for the establishment and maintenance of cell polarity, subcellular signaling and uptake of nutrients into specialized cells, but also for plant cell interactions with pathogenic and symbiotic microbes. Endocytosis starts by vesicle formation at the plasma membrane and progresses through early and late endosomal compartments. In these endosomes cargo is sorted and it is either recycled back to the plasma membrane, or degraded in the lytic vacuole. This book presents an overview of our current knowledge of endocytosis in plants with a main focus on the key molecules undergoing and regulating endocytosis. It also provides up to date methodological approaches as well as principles of protein, structural lipid, sugar and microbe internalization in plant cells. The individual chapters describe clathrin-mediated and fluid-phase endocytosis, as well as flotillin-mediated endocytosis and internalization of microbes. The book was written for a broad spectrum of readers including students, teachers and researchers.
Urban areas have been caught up in a turbulent process of transformation over the past 50 years and changes have been rapid, with issues such as mobility, nature, water management, energy use and public space featuring prominently._x000D_ In each Olympic year since 1988, the Faculty of Architecture at Delft University of Technology has held an international conference focusing on the connection between research and design, exploring the field of tension between science, technology and art._x000D_ This book presents the proceedings of the latest in this series of conferences: New Urban Configurations, held in Delft, the Netherlands, in October 2012 in collaboration with the European Associati...
This book primarily focuses on rigorous mathematical formulation and treatment of static problems arising in continuum mechanics of solids at large or small strains, as well as their various evolutionary variants, including thermodynamics. As such, the theory of boundary- or initial-boundary-value problems for linear or quasilinear elliptic, parabolic or hyperbolic partial differential equations is the main underlying mathematical tool, along with the calculus of variations. Modern concepts of these disciplines as weak solutions, polyconvexity, quasiconvexity, nonsimple materials, materials with various rheologies or with internal variables are exploited. This book is accompanied by exercises with solutions, and appendices briefly presenting the basic mathematical concepts and results needed. It serves as an advanced resource and introductory scientific monograph for undergraduate or PhD students in programs such as mathematical modeling, applied mathematics, computational continuum physics and engineering, as well as for professionals working in these fields.
This book collects wide-ranging contributions such as case studies, reviews, reports on technological developments, outputs of research/studies, and examples of successful projects, presenting current knowledge and raising awareness to help the agriculture and forestry sectors find solutions for mitigating climate variability and adapting to change. It brings the topic of ecosystem services closer to education and learning, as targeted by the Framework Convention on Climate Change and the Paris Agreement, the 2030 Agenda for Sustainable Development and the EU Biodiversity Strategy to 2020. Climate change and its impacts on agriculture and agroforestry have been observed across the world during the last 50 years. Increasing temperatures, droughts, biotic stresses and the impacts of extreme events have continuously decreased agroforestry systems’ resilience to the effects of climate change. As such, there is a need to adapt farming and agroforestry systems so as to make them better able to handle ever-changing climate conditions, and to preserve habitats and ecosystems services.
The Bloomsbury Handbook of Sound Art explores and delineates what Sound Art is in the 21st century. Sound artworks today embody the contemporary and transcultural trends towards the post-apocalyptic, a wide sensorial spectrum of sonic imaginaries as well as the decolonization and deinstitutionalization around the making of sound. Within the areas of musicology, art history, and, later, sound studies, Sound Art has evolved at least since the 1980s into a turbulant field of academic critique and aesthetic analysis. Summoning artists, researchers, curators, and critics, this volume takes note of and reflects the most recent shifts and drifts in Sound Art--rooted in sonic histories and implying future trajectories.
The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world. The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.