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Radiobiology of Glioblastoma
This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanist...
AACR 2022 Proceedings: Part A Online-Only and April 10
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Tumor Markers Research Perspective
Tumour markers are molecules occurring in blood or tissue that are associated with cancer, and whose measurement or identification is useful in patient diagnosis or clinical management. This book analyses potential signals of cancerous tumours, otherwise known as markers or indicators. This includes, direct and rapid determination of cancer antigen, potential tumour markers for cholangiocarcinoma, melanoma inhibitory activity, metastatic uveal melanoma, measurement of tumour oxygenation, bladder cancer markers, epithelial cell adhesion and progression markers in prostate tumours.
Glioblastoma: State of the Art and Future Perspectives
Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research.
Cancer, Intimacy and Sexuality
This book provides a wide-ranging overview of the sexual consequences of cancer and its treatment with the aim of equipping physicians and other health care providers with the awareness and knowledge required in order to offer patients effective treatment. While sexuality may not be the primary focus for cancer patients, at some point, whether because of sexual changes or relationship issues, many patients come to acknowledge the effects that cancer and its treatment have had on their sexuality. Although the impacts are frequently similar, significant variation is observed. Some patients experience changes in all phases of sexual response, while others experience none; moreover, the conseque...
Anticancer Research
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Evolution of Phytochemicals and Phytotherapies in the Treatment and Management of Cancer: Targeted Strategies in Cancer Precision Medicine
There is a rising recurrence of cancers in humans and related complications of chemotherapeutic agents that reduce the clinical potency of numerous anticancer agents, including those which are currently in use. Hence, there is a consistent need for the development of alternative or synergistic anticancer drugs with lower side complications. One imperative approach to develop novel anticancer agents with potent efficiency is to discover natural resource-derived bioactive compounds. Diverse phytochemical constituents (like vincristine, vinblastine, taxol analogs etc.) derived from plants have been manifested as effective therapeutics in the treatment, prevention and management of cancer. There...
Avventure nell’essere umano
Scriveva Leonardo da Vinci che l’uomo è un microcosmo, un mondo in scala ridotta con le ossa a far da montagne, il cuore a far da grande e mobile oceano, il sistema circolatorio a somiglianza dei fi umi e dei corsi d’acqua. Medico, viaggiatore e scrittore, Gavin Francis riprende questa idea e ci conduce alla scoperta del corpo umano e del suo legame con l’avventura di esistere. Dal cranio al calcagno, dalle circonvoluzioni del cervello ai segreti meccanismi che regolano il cuore o i reni, dal mistero del concepimento e della nascita guidati dall’istinto sessuale, al fegato e le sue complesse simbologie, fino alla meravigliosa ingegneria del piede, che ha permesso all’uomo di entrare eretto nella storia dell’evoluzione. Una serie di spedizioni per riscoprire la meravigliosa e talvolta fragile macchina che ci consente di interagire con l’ambiente, di muoverci e di comprendere i nostri simili, filtrate attraverso la diretta esperienza della professione medica e la quotidiana osservazione dell’umanità nella salute e nella malattia. Un libro di sorprendenti avventure nel più aff ascinante e misterioso dei territori, quello della vita umana.
