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Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved therapies are therefore desperately needed.Incretins are short peptide hormones released from the gut in response to food transit. These hormones regulate a plethora of processes to control food intake, body weight and glucose homeostasis. This is one of the fastest areas of growth within diabetes research, and over the past decade, increasing numbers of novel diabetes drugs — many based on incretin action — have been added to the therapeutic armoury.Following an introduction detailing the historical perspective and discovery of incr...
When Sandy's mother, an impoverished drunk in nineteenth-century London, gives birth to a baby girl, Sandy tries to care for her, and when she goes missing he must endure many difficulties before they are reunited.