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Follow this multi-disciplinary, scientific study as it examines the evidence of a great global catastrophe that occurred only 11,500 years ago. Crustal shifting, the tilting of Earth's axis, mass extinctions, upthrusted mountain ranges, rising and shrinking land masses, and gigantic volcanic eruptions and earthquakes--all indicate that a fateful confrontation with a destructive cosmic visitor must have occurred. The abundant geological, biological, and climatological evidence from this dire event calls into question many geological theories and will awaken our memories to our true--and not-so-distant--past.
Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.
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