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Categorical Structures and Their Applications
The book collects original research papers on applied categorical structures, most of which have been presented at the North-West European Category Seminar 2003 in Berlin. The spectrum of these mathematical results reflects the varied interests of Horst Herrlich OCo one of the leading category theorists of the world OCo to whom this volume is dedicated in view of his 65th birthday. The book contains applications of categorical methods in various branches of mathematics such as algebra, analysis, logic and topology, as well as fuzzy structures and computer science. At the end of the book the reader will find a complete list of Horst HerrlichOCOs publications. The proceedings have been selected for coverage in: . OCo Index to Scientific & Technical Proceedings- (ISTP- / ISI Proceedings). OCo Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings). OCo CC Proceedings OCo Engineering & Physical Sciences."
Peptides as Drugs
By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class. The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs. With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.
Foundations of Topology
A new foundation of Topology, summarized under the name Convenient Topology, is considered such that several deficiencies of topological and uniform spaces are remedied. This does not mean that these spaces are superfluous. It means exactly that a better framework for handling problems of a topological nature is used. In this setting semiuniform convergence spaces play an essential role. They include not only convergence structures such as topological structures and limit space structures, but also uniform convergence structures such as uniform structures and uniform limit space structures, and they are suitable for studying continuity, Cauchy continuity and uniform continuity as well as convergence structures in function spaces, e.g. simple convergence, continuous convergence and uniform convergence. Various interesting results are presented which cannot be obtained by using topological or uniform spaces in the usual context. The text is self-contained with the exception of the last chapter, where the intuitive concept of nearness is incorporated in Convenient Topology (there exist already excellent expositions on nearness spaces).
Cell Adhesion and Human Disease
Experts in their respective fields present papers concerned with the range of human diseases caused by defective or abnormal functioning of cell adhesion molecules. Discusses new therapeutic approaches to these maladies.
Induced Effects Of Genotoxic Agents In Eukaryotic Cells
This book provides an understanding of the consequences of induced proteins in the toxicological response of cells to chemical and radiation damage to DNA and will be helpful in creating proper mathematical models for extrapolation to low doses and assessing human exposure or cellular injury.
Adhesion in Leukocyte Homing and Differentiation
This volume of Current Topics in Microbiology and Immunology was planned in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held at the Basel Institute for Immunology in November 1992, and many of the workshop speakers have contributed to it. Cell adhesion is one of the most dynamic fields of biological research and presented in this book is the current knowledge on the structure and function of the major families of cell adhesion molecules-the integrins, the selectins, the immunoglobulin superfamily, and CD44. Complex interactions between the members of these families mediate diverse adhesion functions, including leukocyte-leukocyte interact...
Recent Advances in Glucocorticoid Receptor Action
The long-term use of glucocorticoids is associated with several deleterious effects. Attempts to separate the beneficial from the adverse effects of these compounds have met with varying degrees of difficulty. The discovery of distinct modes of action of the glucocorticoid receptor, the protein that mediates glucocorticoid action has opened up many possibilities for improving glucocorticoid therapy. This book provides an in-depth overview of the molecular actions of the glucocorticoid receptor and discusses the chances of an imminent identification of selective glucocorticoid agonists. Such componds should fulfill all the criteria of a glucocorticoid but should lack the sideeffects so far linked with classical glucocorticoids.
Attempts to Understand Metastasis Formation II
Within the last decade the molecular biology of tumor models has revealed the identification of several metastasis- related molecules. These volumes attempt to review the most recent approaches of their mechanisms, regulation and way to treat their malignant alterations. The first volume covers the presentation of proteases and inhibitors and their role in invasion of tumor cells, also cell adhesion molecules and their interaction with the extracellular matrix. In the second volume the regulation of tumor progression and angiogenesis by cytokines, growth factors and motility factors is outlined. The third volume deals with detection of micrometastases and therapeutic approaches, such as immunotherapy, gene therapy, chemotherapy and surgical strategies to combat metastatic spread.
Categorical Perspectives
"Categorical Perspectives" consists of introductory surveys as well as articles containing original research and complete proofs devoted mainly to the theoretical and foundational developments of category theory and its applications to other fields. A number of articles in the areas of topology, algebra and computer science reflect the varied interests of George Strecker to whom this work is dedicated. Notable also are an exposition of the contributions and importance of George Strecker's research and a survey chapter on general category theory. This work is an excellent reference text for researchers and graduate students in category theory and related areas. Contributors: H.L. Bentley * G. Castellini * R. El Bashir * H. Herrlich * M. Husek * L. Janos * J. Koslowski * V.A. Lemin * A. Melton * G. Preuá * Y.T. Rhineghost * B.S.W. Schroeder * L. Schr"der * G.E. Strecker * A. Zmrzlina
