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Central Nervous System Monitoring in Anesthesia and Intensive Care
Research in electrophysiologic monitoring in anesthesia and intensive care has focussed mostly on questions pertinent for patient care: First how to quantitate drug effects on brain electrical activity and the degree of anesthetic-induced suppression of the central nervous system. Second, how to monitor functional impairment following cerebral ischemia and hypoxia. And third, how to differ entiate between drug-induced effects on the central nervous system and deleteri ous events related to reductions in cerebral blood flow and/or oxygen delivery. Even though progress has been achieved over the last 10 years in this field and fascinating new techniques have been developed, it is still not cle...
Quantitative Anaesthesia
Quantitative anaesthesia - exact registration of the degree of anaesthesia - has long been the anaesthetist's dream. Such pre cision could decrease the risk for the patient. Can -this dream now be realized in the foreseeable future? And can the quantifi cation be technically verified? This workshop was organized for these questions to be discussed by a group of experts. Schleswig-Holstein was a logical location for such a gathering. Medical and associated technical advances have socioeconomic consequences: in Schleswig-Holstein there are nowadays more jobs in medical technology than in the traditional shipbuilding industry. The encouragement of medical research and related technical innovati...
On the Study and Practice of Intravenous Anaesthesia
close circle of anaesthetic scientists but, with the help of computer technology, has greatly influenced the practice of the modern clinical anaesthesiologist. The efforts of anaesthesiologists, pharmaceutical companies, and the development of the internet has lead to a situation that now almost every anaesthesiologist can be in close contact to anaesthetic pharmacology computer simulation pro grams and target controlled infusion devices. These two tools allow us to in crease our understanding and improve the controllability of anaesthetic drug administration, on site, in the operating theatre. In Europe the growing enthusi asm regarding the study and practice of intravenous anaesthesia has ...
Inhalation Anesthetics
In 1981, the Institute of Anesthesiology at the Ludwig Maximil ian University of Munich organized a first international sympo sium on inhalation anesthetics. In 1982, the most important con tributions were published in the series Anaesthesiology and Inten sive Care Medicine. At that time, the interest of European anes thesiologists was focused on isoflurane, which had just been in troduced for clinical purposes. Studies on this product had al ready been appearing for years in the American literature. This book deals once more with all three inhalation anesthetics, but places particular emphasis on isoflurane. In contrast to the situa tion in 1981, extensive experimental and clinical investig...
Generalized Predictive Control And Bioengineering
Predictive control is a powerful tool in dealing with those processes with large time delays. Generalized Predictive Control GPC is the most popular approach to the subject, and this text discusses the application of GPC starting with the concept of long-range predictive control and its need in medicine particularly automated drug deliveries.; The concept of adaptation is also emphasized with respect to patient-to-patient parameter variations. Subsequent chapters discuss interactions, comparisons and various aspects of GPC. The book concludes by putting into perspective the generic nature of the architecture built around GPC and which provides model-based fault diagnosis with control.
Yearbook of Intensive Care and Emergency Medicine
The Yearbook compiles the most recent, widespread developments of experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
55th Anniversary of the German Society for Anaesthesiology and Intensive Care
This book presents to all those who are interested in the history of Anaesthesiology historical details and information on the development of anaesthesiology in Germany and the remarkable growth of our Society. At the founding session of the German Society of Anaesthesia in Munich on 10 April 1953 42 persons had signed the founding documents. Today about 12,000 anaesthetists are members of the German Society of Anaesthesiology and Intensive Care Medicine, making the DGAI the biggest national society within ESA. Well known are the pioneering contributions of German scientists and surgeons to the development of general, regional and local anaesthesia during the 19th and the beginning of the 20th centuries. But less known outside Germany are the reasons for the delayed evolution of anaesthesiology as a specialty of its own in German medicine, far later than in the UK, Scandinavia or the USA. In this book you will find answers to this question and detailed information on the successful evolution of anaesthesiology especially at the Faculties of Medicine at German universities.
Adenoviral Vectors for Gene Therapy
Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials
