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Cognitive Biology
In particular, it is shown that this activity is grounded on a theory of information based on Bayesian probabilities.
Metodika Centra provázení
Základním cílem metodiky je sjednocení pravidel pro působení poradenských pracovníků v jednotlivých střediscích Centra provázení při vybraných nemocnicích a vytvoření dokumentu metodické podpory pro další nemocnice, které budou chtít systém Provázení zařadit mezi nabízené služby pro dětské pacienty a jejich rodiče, tedy definovat podmínky pro systémové poskytování podpory rodičům dětských pacientů.
Genetics Abstracts
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Genomic Imprinting
Genomic imprinting is the process by which gene activity is regulated according to parent of origin. Usually, this means that either the maternally inherited or the paternally inherited allele of a gene is expressed while the opposite allele is repressed. The phenomenon is largely restricted to mammals and flowering plants and was first recognized at the level of whole genomes. Nuclear transplantation experiments carried out in mice in the late 1970s established the non-equivalence of the maternal and paternal genomes in mammals, and a similar conclusion was drawn from studies of interploidy crosses of flowering plants that extend back to at least the 1930s. Further mouse genetic studies, involving animals carrying balanced translocations (reviewed in Chapter 3), indicated that imprinted genes were likely to be widely scattered and would form a minority within the mammalian genome. The first imprinted genes were identified in the early 1990s; over forty are now known in mammals and the list continues steadily to expand.
Calcareous Mires of Slovakia
Slovakia is blessed with an abundance of natural beauties, and some of them are quite unique within Europe. Calcareous fens, which are peat and travertine (CaCO3) depositing wetlands are such rare ecosystems and in Slovakia they are located almost exclusively in the Western Carpathian Mountains. Calcareous fens are hot spots of biodiversity and some protected and almost untouched sites are discussed in this book. Such reference area are unique natural archives, and are very suitable for studying their past development and history. An international team of peatland scientists tried to unravel the hydrological and geochemical processes behind the development of calcareous fens and identify the...
DNA Methylation Protocols
DNA Methylation Protocols offer a set of readily reproducible protocols of the analysis of DNA methylation and methylases. These powerful methods provide the tools necessary for studying methylation at both the global level and the level of sequence, and include many techniques for identifying genes that might be aberrantly methylated in cancer and aging. Additional methods cover genome-wide analysis of abnormal DNA methylation and the isolation and measurement of demethylases and related proteins.
Forgotten Times and Spaces
Kniha přináší přes čtyřicet příspěvků mezinárodního kolektivu autorů a jejím záměrem je především shromáždit a popsat střípky předchozích, zapomenutých způsobů života. Lidský život a evoluce překlenuje různé historické epochy i místa, osud člověka se však zdá neúprosný, protože svědkové, vzpomínky i hmatatelné důkazy lidské existence se nevyhnutelně vytrácejí. Kniha současně odráží výsledky široké, mezinárodní spolupráce Jiřího A. Svobody, významného vědce, s autory příspěvků, včetně těch, kteří se jeho dílem inspirují.
Stochastic Regulation of the Interleukin-4 Gene
This book focuses on the expression variability of highly regulated genes in multi-cellular organisms through a multidisciplinary approach combining quantitative measurements and mathematical modeling. For this purpose, the cytokine gene Interleukin-4 (IL-4) in murine type-2 (Th2) lymphocytes was chosen as prototypical model system of an inducible gene regulated at the epigenetic and transductional level. As many cytokines, IL-4 is expressed in a probabilistic manner, but the underlying molecular mechanisms behind this phenomenon are still unresolved. Through an iterative process of quantitative measurements and mathematical analysis, the author develops a computational model able to predict...
