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Human Cell Culture Protocols
A thoroughly revised and updated collection readily reproducible techniques for culturing human cells. This new edition includes a wide range of human cell types relevant to human disease and new chapters on fibroblasts, Schwann cells, gastric and colonic epithelial cells, and parathyroid cells. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Textbook of Diabetes
Over three editions the Textbook of Diabetes has built a reputation as a book that is extremely well-organized and easy to navigate, with exceptional illustrations and an excellent blend of clinical and scientific content. Previously edited by John Pickup and Gareth Williams this fourth edition has four brand new editors from across the globe. The editors have assembled an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The new Textbook of Diabetes has been restructured into 12 parts in one accessible volume and is designed with the busy diabetes care team in mind....
The Role of Pregnancy Nutrition in Maternal and Offspring Health
In pregnancy, maternal nutrition sustains and nourishes the developing child. Imbalances in either the direction of nutritional excess or deficiency can have adverse consequences for child health. In addition, more research now suggests that good pregnancy nutrition influences child health beyond pregnancy and delivery. This includes modifying the risk of child health outcomes as they enter childhood and adulthood through influences on placental development, hormonal pathways, and organ structure and function. Poor pregnancy nutrition may also compromise maternal health during pregnancy, which may have long-term consequences for women’s health. Understanding the biological and social mecha...
Obesity in Childhood and Adolescence
Obesity in childhood and adolescence has reached epidemic proportions in all industrialized countries around the world. Its impact on individual lives as well as on health economics has to be recognized by physicians and the public alike. Among the most common consequences of obesity in the adolescent are hypertension, dyslipidemia, back pain and psychosocial problems. Therapeutic strategies include psychological and family therapy, lifestyle/behavior modification and nutrition education. The role of regular exercise and exercise programs is emphasized. Surgical procedures and drugs used in adult obesity are still not generally recommended for obese adolescents. This book aims to increase ph...
Pharmacotherapy of Obesity
Primarily intended for physicians and health care professionals who are treating obese patients, this book explores current and future options for drug treatment of obesity puts them into perspective against available alternative treatments. Distinguished scientists and clinical investigators provide reviews of each individual topic, covering a wide range of subjects from pathophysiology of obesity to the benefits of weight loss. The core sections on pharmacotherapy deal with currently available drugs and drugs in pre-clinical development. These sections are complemented with sections on non-drug treatment and general therapeutic aspects. This design provides an integrated view of therapeutic approaches to the treatment of obesity and its associated syndromes.
Handbook of Obesity
Offering perspectives on the history, prevalence and genetics of obesity, this book examines the origins and etiology of obesity. It considers the relationship between behavioural neuroscience and obesity.
Adipose Tissue Protocols
Adipose tissue is recognized to be exquisitely sensitive to hormone action, and is also now recognized as a secretory and endocrine organ required for reproduction and good health. Adipocytes are “smart” cells able within the tissue to communicate with surrounding cells, but also with various organs, particularly via leptin acting on the central nervous system. Brown adipose tissue (BAT) and white adipose tissue (WAT) are known to be distinct tissues, whereas the heterogeneity of WAT depots is well est- lished. Unfortunately, excess WAT leads to obesity, which is the most common health problem in industrialized countries. Therefore, from both a scientific and a technical point of view, t...
To Eat or Not To Eat Meat
Increasingly, people are shifting to vegetarian, plant-based, or vegan diets. This shift is having profound effects on our social interactions, and this is the focus of this book. Becoming a vegetarian or vegan involves more than just changing your diet. It can change how you socially and emotionally connect with family, friends and the broader community, shape your outlook on life, and open up new worlds and contacts. It can also lead to uncomfortable situations, if dietary choices involving a rejection of meat are read by others as an ethical and moral judgement on mainstream dietary choices. This book adopts an innovative narrative approach, and draws on stories across the globe to consid...
Bone Marrow Adipose Tissue: Formation, Function, and Impact on Health and Disease
Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role in normal physiology and development. Bone marrow adiposity further increases with ageing and in diverse clinical conditions, including major public health challenges such as osteoporosis. Yet despite this abundance and compelling clinical potential, bone marrow adipocytes have received surprisingly little attention from the biomedical research community. Thankfully, this is now beginning...
