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Primarily intended for physicians and health care professionals who are treating obese patients, this book explores current and future options for drug treatment of obesity puts them into perspective against available alternative treatments. Distinguished scientists and clinical investigators provide reviews of each individual topic, covering a wide range of subjects from pathophysiology of obesity to the benefits of weight loss. The core sections on pharmacotherapy deal with currently available drugs and drugs in pre-clinical development. These sections are complemented with sections on non-drug treatment and general therapeutic aspects. This design provides an integrated view of therapeutic approaches to the treatment of obesity and its associated syndromes.
The World Health Organization (WHO) has declared obesity a global epidemic. Its prevalence has more than doubled since 1980, causing a myriad of health problems for children and adults. Obesity: Epidemiology, Pathophysiology, and Prevention, Second Edition explores the molecular mechanisms and pathophysiology leading to obesity and metabolic disorders. It examines the safety of obesity drugs and drug development strategies as well as the role of physical activity, nutrition, and nutraceutical supplements in obesity treatment and prevention. With contributions from a cadre of internationally known experts, the book covers a spectrum of essential topics related to this widespread phenomenon, i...
Bestselling author David Ewing Duncan takes the ultimate high-tech medical exam, investigating the future impact of what's hidden deep inside all of us David Ewing Duncan takes "guinea pig" journalism to the cutting edge of science, building on award-winning articles he wrote for Wired and National Geographic, in which he was tested for hundreds of chemicals and genes associated with disease, emotions, and other traits. Expanding on these tests, he examines his genes, environment, brain, and body, exploring what they reveal about his and his family's future health, traits, and ancestry, as well as the profound impact of this new self-knowledge on what it means to be human. David Ewing Duncan...
Brown adipose tissue (BAT) has long been recognized as a key thermogenic tissue in eutherian mammals. Brown fat cells contain large numbers of highly specialized mitochondria that oxidize fat and carbohydrate to produce heat. This metabolic inefficiency is due to the presence of Ucp1 in the inner mitochondrial membrane of brown fat cells which dissociates the electrochemical gradient from ATP production. BAT presumably evolved to protect animals against hypothermia in response to cold exposure. However, energy expended by BAT has the added benefit of counteracting obesity and associated metabolic disease, at least in rodents. A very large number of studies have consistently shown that mice c...
Taking an innovative approach to the life and legend of Marilyn Monroe (1926-1962), this biographical dictionary concentrates on her circle of friends, acquaintances and coworkers--1618 in all. Distilled from hundreds of celebrity biographies are references to, and quotes about, the iconic Hollywood sex symbol from such diverse personalities as architect Frank Lloyd Wright, Israeli diplomat Abba Eban, beat poet Jack Kerouac, novelist Somerset Maugham, jazz singer Ella Fitzgerald, counterculture guru Timothy Leary and evangelist Aimee Semple McPherson, to name but a few. All of these remarkable people have, in one way or another, crossed paths with the magnificent Monroe. The entries in this volume (with source listings for further reading and research) confirm the fact that Marilyn Monroe remains a figure of enduring fascination five decades after her death.
Written with uncensored access to Olivier's personal papers, love letters and diaries, a landmark biography of the greatest actor of the twentieth century
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A trio of heart-stopping thrillers from the New York Times–bestselling author—including the “vibrant and cerebral” #1 international bestseller, The Eight (Los Angeles Times). People magazine said of Katherine Neville’s debut novel and #1 international bestseller, The Eight: “With alchemical skill, Neville blends modern romance, historical fiction, and medieval mystery . . . and comes up with gold.” Mining a fertile territory of international intrigue, complex conspiracies, history-spanning storylines, and unstoppable female heroines, Neville has arguably struck gold with all three of these thrillers. A Calculated Risk: In this New York Times Notable Book, computer expert Verity...