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Parkinson's Disease: Cell Vulnerability and Disease Progression
Download PDF Download EPUB Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal abo...
The Proteasome in Neurodegeneration
In the last 50 years a wealth of information has allowed us to understand the contribution of various regulatory factors that alter mRNA and protein s- thesis to a variety of physiological and pathological conditions. However, such regulation is only one of many factors that contribute to the levels of a given p- tein. One major factor that has been relatively obscure until recently has been the contribution of protein degradation to the regulation of the steady state level of protein expression and protein function. This rapidly evolving field has made a significant mark on the scientific community, as highlighted by the Award of the Nobel Prize in Chemistry for 2004 to Aaron Ciechanover, A...
In Their Footsteps
In Their Footsteps is a Genealogical compilation of approximately 900 individuals and the story of how this Palmer Family came to be and where it came from. As one might expect, the geography of a complicated genealogy such as this one has several disparate locations of importance. Thankfully, these ancestors chose to cluster around a select few well documented locales: New England, lower New York State, Northeastern New Jersey, Central New York State and the upper Saint John River valley in New Brunswick, Canada. It also tells the story of how and why Samuel Benson Leydecker chose exile in the wilderness of New Brunswick over the prospects of staying in the Hackensack River valley of New Jersey after the American Revolution.
An Updated Genealogy
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Ride Out the Wilderness
"Often considered alienated from mainstream culture and consigned to negative environments, Afro-American writers have created alternative spatial and geographical metaphors to develop a positive sense of individual and cultural identity. Melvin Dixon demonstrates how three principal figures of the land--the wilderness, the underground, and the mountaintop--have become places of refuge and cultural revitalization for the performance of identity, from early slave songs and fugitive narratives to modern and contemporary fiction"--Jacket.
MLA International Bibliography of Books and Articles on the Modern Languages and Literatures
Vols. for 1969- include ACTFL annual bibliography of books and articles on pedagogy in foreign languages 1969-
