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The Proteasome in Neurodegeneration
In the last 50 years a wealth of information has allowed us to understand the contribution of various regulatory factors that alter mRNA and protein s- thesis to a variety of physiological and pathological conditions. However, such regulation is only one of many factors that contribute to the levels of a given p- tein. One major factor that has been relatively obscure until recently has been the contribution of protein degradation to the regulation of the steady state level of protein expression and protein function. This rapidly evolving field has made a significant mark on the scientific community, as highlighted by the Award of the Nobel Prize in Chemistry for 2004 to Aaron Ciechanover, A...
In Their Footsteps
In Their Footsteps is a Genealogical compilation of approximately 900 individuals and the story of how this Palmer Family came to be and where it came from. As one might expect, the geography of a complicated genealogy such as this one has several disparate locations of importance. Thankfully, these ancestors chose to cluster around a select few well documented locales: New England, lower New York State, Northeastern New Jersey, Central New York State and the upper Saint John River valley in New Brunswick, Canada. It also tells the story of how and why Samuel Benson Leydecker chose exile in the wilderness of New Brunswick over the prospects of staying in the Hackensack River valley of New Jersey after the American Revolution.
An Updated Genealogy
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Parkinson's Disease: Cell Vulnerability and Disease Progression
Download PDF Download EPUB Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal abo...
Growth Curve Models and Applications
Growth curve models in longitudinal studies are widely used to model population size, body height, biomass, fungal growth, and other variables in the biological sciences, but these statistical methods for modeling growth curves and analyzing longitudinal data also extend to general statistics, economics, public health, demographics, epidemiology, SQC, sociology, nano-biotechnology, fluid mechanics, and other applied areas. There is no one-size-fits-all approach to growth measurement. The selected papers in this volume build on presentations from the GCM workshop held at the Indian Statistical Institute, Giridih, on March 28-29, 2016. They represent recent trends in GCM research on different subject areas, both theoretical and applied. This book includes tools and possibilities for further work through new techniques and modification of existing ones. The volume includes original studies, theoretical findings and case studies from a wide range of applied work, and these contributions have been externally refereed to the high quality standards of leading journals in the field.
Ride Out the Wilderness
"Often considered alienated from mainstream culture and consigned to negative environments, Afro-American writers have created alternative spatial and geographical metaphors to develop a positive sense of individual and cultural identity. Melvin Dixon demonstrates how three principal figures of the land--the wilderness, the underground, and the mountaintop--have become places of refuge and cultural revitalization for the performance of identity, from early slave songs and fugitive narratives to modern and contemporary fiction"--Jacket.
Consuming Innocence
"This is an academic look at the contribution of popular culture to the loss if innocence in today's children."--Publisher.
