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This four-volume set LNCS 13701-13704 constitutes contributions of the associated events held at the 11th International Symposium on Leveraging Applications of Formal Methods, ISoLA 2022, which took place in Rhodes, Greece, in October/November 2022. The contributions in the four-volume set are organized according to the following topical sections: specify this - bridging gaps between program specification paradigms; x-by-construction meets runtime verification; verification and validation of concurrent and distributed heterogeneous systems; programming - what is next: the role of documentation; automated software re-engineering; DIME day; rigorous engineering of collective adaptive systems; formal methods meet machine learning; digital twin engineering; digital thread in smart manufacturing; formal methods for distributed computing in future railway systems; industrial day.
The global COVID-19 pandemic, the resulting lockdown imposed in many countries, as well as related safety measures taken by governments and authorities, have posed significant challenges to classical music culture. However, they may also have had a stimulating effect on music festivals and opera houses’ streaming offerings. This book brings together experts from the fields of musicology and music management to share their current empirical research findings on the pandemic-evoked digital transformation of the classical music scene, addressing either the institutional or the reception perspective. Furthermore, it documents discussions with opera dramaturgs and artistic directors, as well as...
Transcription factors are nuclear proteins that control the rate of gene expression, activating or repressing transcription in a context-dependent manner. These regulators lie at the heart of most cell fate decisions of immune cells, guiding the initiation and maintenance of lineage identity and controlling the cell-type-specific gene expression that underpins the unique functions of each immune cell lineage. As such transcription factors are of critical importance for a healthy immune system, with mutation of specific factors leading to immune dysregulation with immunodeficiency and autoimmunity. In addition, perturbation of transcription factors known to regulate immune cell function have been implicated in the genesis of haematological malignancies through chromosomal translocation, over-expression or genetic deletion.
This open access book, edited and authored by a team of world-leading researchers, provides a broad overview of advanced photonic methods for nanoscale visualization, as well as describing a range of fascinating in-depth studies. Introductory chapters cover the most relevant physics and basic methods that young researchers need to master in order to work effectively in the field of nanoscale photonic imaging, from physical first principles, to instrumentation, to mathematical foundations of imaging and data analysis. Subsequent chapters demonstrate how these cutting edge methods are applied to a variety of systems, including complex fluids and biomolecular systems, for visualizing their stru...
Evidence-Based Imaging is a user-friendly guide to the evidence-based science and merit defining the appropriate use of medical imaging in both adult and pediatric patients. Chapters are divided into major areas of medical imaging and cover the most prevalent diseases in developed countries, including the four major causes of mortality and morbidity: injury, coronary artery disease, cancer, and cerebrovascular disease. This book gives the reader a clinically-relevant overview of evidence-based imaging, with topics including epidemiology, patient selection, imaging strategies, test performance, cost-effectiveness, radiation safety and applicability. Each chapter is framed around important and...
This volume constitutes the refereed proceedings of the 17th International Symposium on Graph Drawing, GD 2009, held in Chicago, USA, during September 2009. The 31 revised full papers and 4 short papers presented were carefully reviewed and selected out of 79 submissions. Furthermore, 10 posters were accepted in a separate submission process.