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This book provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer. Book also summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail. Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5-flourouracil.
Reveals the relationship between the rise of political violence in West Germany to the unprecedented growth of consumption
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Learn the basics—and more—of nanoscale computation and communication in this emerging and interdisciplinary field The field of nanoscale computation and communications systems is a thriving and interdisciplinary research area which has made enormous strides in recent years. A working knowledge of nanonetworks, their conceptual foundations, and their applications is an essential tool for the next generation of scientists and network engineers. Nanonetworks: The Future of Communication and Computation offers a thorough, accessible overview of this subject rooted in extensive research and teaching experience. Offering a concise and intelligible introduction to the key paradigms of nanoscale...
Situated at the intersection between social work and education, social pedagogy is an original and dynamic academic and professional tradition. It can be found across most European countries and shows great variety, being closely connected to specific national - and sometimes even regional cultures and structures. Yet despite this diversity, social pedagogy also has many common features, cross-nationally. The aim of the book is to illustrate this diversity via a selection of case studies from Denmark, France, Germany, Poland and Sweden. Although social pedagogy is, in many countries, a profession that represents a sizeable workforce, very little has been written about it from a European pers...
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Although pancreatic cancer is one of the most serious forms of cancers, the lack of clinical symptoms often limits curative treatment options. This book gives insight into the current understanding of the management of pancreatic cancer and considers recent findings in cancer research. It provides answers to questions of how to know when cancer is respectable, how to proceed when the diagnosis comes too late for a curative approach, and how to assess different study results.
In evolutionary time scales natural disturbances have affected the vegetation on Earth. During the Quaternary the forest biomes of the tropics were subjected to manifold disturbances. Climate changes and climate oscillations were associated with changing precipitation and drought regimes, flooding, siltation, landslides, etc. The prehistorical forest was also influenced by the effects of large wildlife populations. Large-scale catastrophies in the forest biomes were mainly caused by abiotic environmental alterations, the small-scale disturbances were and still are related to both biotic and abiotic processes. Both the large-and the small-scale disturbances have played a significant role in s...
Jewish historiography tends to stress the religious, cultural, and political aspects of the past. By contrast the “economy” has been pushed to the margins of the Jewish discourse and scholarship since the end of the Second World War. This volume takes a fresh look at Jews and the economy, arguing that a broader, cultural approach is needed to understand the central importance of the economy. The very dynamics of economy and its ability to function depend on the ability of individuals to interact, and on the shared values and norms that are fostered within ethnic communities. Thus this volume sheds new light on the interrelationship between religion, ethnicity, culture, and the economy, revealing the potential of an “economic turn” in the study of history.
Nazi Germany's campaign against 'degenerate art' and its persecution of experimental artists pushed the avant-garde in Germany to the brink of extinction. This book examines how the avant-garde came back after the war, reconfiguring its aesthetics in the light of those years.