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Childhood Leukemias
New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood.
An Epicurean Odyssey: A Road Trip Around The Iberian Peninsula
Robert Giorgione has been a highly-respected, award-winning sommelier since 1997, having worked in some of the most high profile restaurants in the UK. He has travelled extensively around Spain and Portugal many times and has visited many of the region's vineyards, restaurants, markets and bodegas. Robert is passionate about Iberian food and drink, which includes its own regional produce and cultural diversity. An Epicurean Odyssey: A Road Trip Around The Iberian Peninsula is a personalised journey through food and drink embellished with many mouth-watering stories, recipes and drinks pairings.
Hematology
Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field. Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recen...
The Eighteenth-Century Fortepiano Grand and Its Patrons
“Badura-Skoda addresses the place of the piano in the eighteenth century from the perspective of a scholar and performer” (Eighteenth-Century Music). In the late seventeenth century, Italian musician and inventor Bartolomeo Cristofori developed a new musical instrument—his cembalo che fa il piano e forte, which allowed keyboard players flexible dynamic gradation. This innovation, which came to be known as the hammer-harpsichord or fortepiano grand, was slow to catch on in musical circles. However, as renowned piano historian Eva Badura-Skoda demonstrates, the instrument inspired new keyboard techniques and performance practices and was eagerly adopted by virtuosos of the age, including Scarlatti, J. S. Bach, Clementi, Haydn, Mozart, and Beethoven. Presenting a rich array of archival evidence, Badura-Skoda traces the construction and use of the fortepiano grand across the musical cultures of eighteenth-century Europe, providing a valuable resource for music historians, organologists, and performers. “Badura-Skoda has written a remarkable volume, the result of a lifetime of scholarly research and investigation. . . . Essential.” —Choice
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Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment
Immunotherapy is a form of cancer therapy that harnesses the body's immune system to destroy cancer cells. In recent years, immunotherapies have been developed for several cancers, including advanced melanoma, lung cancer, and kidney cancer. In some patients with metastatic cancers who have not responded well to other treatments, immunotherapy treatment has resulted in complete and durable responses. Given these promising findings, it is hoped that continued immunotherapy research and development will produce better cancer treatments that improve patient outcomes. With this promise, however, there is also recognition that the clinical and biological landscape for immunotherapies is novel and...
