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Case Studies in Immunology: Autoimmune Hemolytic Anemia
This case study is about an autoimmune disease triggered by infection. It describes how Gwendolen Fairfax, a healthy, unmarried 34-year-old bank manager, who developed the sudden onset of fever, cough and anemia, was started on erythromycin by intravenous administration for treatment.
Immune Hemolytic Anemias
Here's a New Edition of Petz & Garratty's classic text, Acquired Immune Hemolytic Anemias, originally published in 1980. The scope of the book has now been expanded to include the full spectrum of autoimmune and alloimmune immune hemolytic anemias including hemolysis associated with transplantation, hemolytic disease of the fetus and newborn, and hemolytic transfusion reactions. Completely revised and updated from beginning to end, it presents authoritative coverage of all of today's best laboratory tests as well as the latest diagnostic and treatment methods. Presents the latest advances in knowledge about hemolytic anemias in neonates, bone marrow transplantation recipients, individuals with autoimmune disorders, and more. Features a significantly expanded section on differential diagnosis that includes disorders such as lymphoma and EBV-associated hemolysis and reflects the latest immunologic assays. Synthesizes the expertise of the world's most respected authorities on the subject.
Autoimmune Hemolytic Anemia (AIHA)
Hemolytic anemia is a clinical condition where red blood cell (RBC) destruction exceeds the ability of the body to supply new ones. In immunohemolytic anemia, the causes of the destruction are antibodies against RBC antigens. These antibodies may be either alloantibodies (isoantibodies), transfused or transferred across the placenta (e.g., in hemolytic anemia of the newborn), or autoantibodies (in AIHA). Once formed, these antibodies bind to the surface of RBCs, marking them for destruction in the blood vessels (intravascular hemolysis) and/or for elimination by phagocytosis by macrophages in the reticulo-endothelial system (extravascular hemolysis). This book presents current research on the symptoms, diagnosis and treatment of AIHA. Chapter One examines oxidative stress in AIHA. Chapter Two discusses AIHA in primary immunodeficiency disorders, while Chapter Three studies AIHA in cancer disorders. Chapter Four reviews AIHA post solid organ transplants. The final chapter reviews the incidence, possible pathophysiology, clinical presentations, management strategies and challenges and outcome after an allogeneic hematopoietic stem cell transplant.
Complement-mediated Hemolytic Anemias, An Issue of Hematology/Oncology Clinics of North America,
This issue of Hematology/Oncology Clinics of North America, guest edted by Dr. Robert Brodsky, is devoted to Complement-mediated Hemolytic Anemias. Articles in this outstanding issue include: Complement: An overview for the clinician; Warm autoimmune hemolytic anemia; Cold Agglutinin Disease; ABO incompatible blood transfusions; Paroxysmal cold hemoglobinuria; Paroxysmal nocturnal hemoglobinuria; Congenital CD59 deficiency; Atypical Hemolytic Uremic Syndrome (HUS); Typical Hemolytic Uremic Syndrome (HUS); Thrombotic thrombocytopenic purpura; and Pharmacologic complement inhibitors.
Immune Hematology
This text provides a concise yet comprehensive overview of the most common autoimmune cytopenias affecting adults and children. The book is divided into four sections, each of which focuses on a major autoimmune cytopenia. The first section features background, pathophysiology, presentation, evaluation, and treatment strategies for immune thrombocytopenia (ITP), the most common cause of antibody-mediated platelet destruction. The second section reviews common forms and treatment strategies for autoimmune hemolytic anemia (AIHA), including a chapter dedicated specifically to Evans Syndrome. The third section comprehensively reviews the pathophysiology, diagnosis and current management approac...
