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Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters
Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.
Cardiovascular Development and Congenital Malformations
Congenital cardiovascular malformations are the single most common form of birth defect. Therefore a better understanding of the mechanisms involved in both normal cardiac development and the formation of cardiovascular structural defects is of tremendous importance. This book brings together the leading scientists from around the world who are actively engaged in studies of the etiology, morphogenesis and physiology of congenital cardiovascular diseases. A broad variety of approaches, techniques, experimental models and studies of human genetics combine to make this a truly outstanding and unique treatise on this pressing topic. Cardiovascular Development and Congenital Malformations is divided into distinct categories, each focusing on a particular aspect of cardiovascular development. Sections are accompanied by editorial overviews which integrate new findings and place the information into a broader context.
Cardiac Pacing
Proceedings of a congress serve the purpose to provide the reader with the latest know ledge in the specific field. They present at least for a limited time period a reference book that allows rapid access to the latest information for the medical profession and for an ongoing of future research. This volume is addressed not only to the participants of the VIIth World Symposium on Cardiac Pacing but to everybody involved in diagnostic and therapeutic cardiac stimula tion. The experience has shown that proceedings of conferences of comparable size are usually published with a considerable time delay limiting its value as a source of prime informa tion. The editors of this volume decided there...
Brugada Syndrome
Sudden Cardiac Death in young is significantly contributed by inheritable cardiac arrhythmia syndromes .The most prevalent and well-studied of them are Brugada Syndrome & QT-pathies .Brugada syndrome is characterized by coved ST-segment elevation in the right precordial electrocardiographic leads and an aborted sudden cardiac death due to ventricular fibrillation in the absence of structural heart disease. There is very scarce data and books written on Brugada syndrome in our country. Many patients with Brugada Syndrome are misdiagnosed even when they present with warning symptoms and signs or after resuscitated cardiac arrest. The fortunate patients who survive the first episode of SCD are also not evaluated and investigated to recognise if these conditions are present. This book is a humble effort to give lucid and comprehensive account of Brugada Syndrome which should enable clinicians to give better understanding of this condition and hence better care to the patients.
