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Biochemical Regulation of Myocardium
This special issue of Molecular and Cellular Biochemistry contains original research papers as well as invited reviews dedi cated, on the occasion of the 40th anniversary of the inauguration of the Heart Research Group in Berlin-Buch that today forms a part there of the Max Delbriick Center for Molecular Medicine, to Professor Albert Wollenberger, founder of the Heart Research Group and for 21 years its head. The papers in this issue are written by researchers working in the field of cardiovascular research who together with Albert Wollenberger share the belief that an integrative application of advances in molecular and cellular biology will lead to new concepts for treatment and prevention...
Practical Methods in Cardiovascular Research
Scientists working or planning to work in the field of cardiovascular research will welcome Methods in Cardiovascular Research as the reference book they have been waiting for. Not only general aspects of cardiovascular research are well presented but also detailed descriptions of methods, protocols and practical examples. Written by leading scientists in their field, chapters cover classical methods such as the Langendorff heart or working heart models as well as numerous new techniques and methods. Newcomers and experienced researchers alike will benefit from the troubleshooting guide in each chapter, the extensive reference lists for advanced reading and the great practical experience of the authors. Methods in Cardiovascular Research is a "must have" for anybody with an interest in cardiovascular research.
Cardiomyocytes – Active Players in Cardiac Disease
This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine. The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.
Detection of Mitochondrial Diseases
In October 1995, the 1st Colloquium on Mitochondria and Myopathies in Halle/Saale was organized in Halle/Saale by the editors of this focused issue. The meeting took up what might be called an East German tradition: from 1976 to 1990 Andreas Schmidt organized seven clinically orientated Colloquia on Myology in Jena, and from 1974 to 1990 a series of twelve Colloquia on Mitochondria focused on basic research aspects was arranged by Wolfgang Kunz in Magdeburg. At those meetings, East Germany was a mediator between East European, West European and American scientists. In continuation of this tradition, scientists from more than 17 countries working on mitochondria as neurologists, biochemists, ...
Membrane Physiopathology
The need for publishing acomprehensive review ofa number ofdifferent membrane pathologiesofmuscleand non-musclecells inillnesses ranging from diabetes toheart disease and cancer lies on to the fact that there are several books dealing with the properties ofnormal cell membranes, although there are very few books focussing on the abnormal membrane behavior. Since the membrane is the critical outer barrier of a cell, this membrane could be the first structure to be affected in some diseases. Research is advancing at the cellular level at a very rapid rate. We can now address questions such as: "How and by what is the mechanism underlying membrane ion channel and receptor dysfunction leading to...
The Carnitine System
In the last few years, derivatives of L-carnitine, such as acetyl-L-carnitine and propionyl-L-carnitine, have been made available to doctors for treatment of specific pathologies. The effects of this family of related carnitine compounds on cardiovascular systems and diseases constitute the major issue addressed in this volume. Although several books on carnitine have been published, a treatise focusing on experimental and clinical aspects of the carnitine family and cardiovascular diseases was lacking. The present book provides the reader with a concise update in this field. The information collected from experts on various aspects of the fascinating compound, carnitine, will be useful for both clinicians and basic scientists.
Purines and Myocardial Protection
A critical review of the most up-to-date research on purines and myocardial protection. The role of purines in reversible `myocardial stunning' and irreversible (myocardial infarction) ischemic injury, ventricular arrhythmias, and ischemic preconditioning is discussed in detail, by experts. All reviews address recent and rather controversial issues on purines and myocardial protection. Mechanisms of cardioprotection of exogenous versus endogenous purines are discussed in detail. The contribution of internationally recognized experts in the field of purines and cardiovascular physiology and in myocardial protection makes this a unique and interesting book for clinicians, basic scientists and students.
