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Parasite Genomics Protocols
Parasite Genomics Protocols, Second Edition expands upon the previous edition with current, detailed methodologies that have been adapted to research parasites in the post genomic era. With new chapters on parasite studies, helminth pathogens, and protocols for undertaking other large-scale ‘omics’ methodologies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Parasite Genomics Protocols, Second Edition offers a wide-ranging collection of diverse methods and protocols for further study into these unique organisms.
Pause and Effect
Over the centuries punctuation has become an essential component of written language. Its primary function is to resolve structural uncertainties in a text, and to signal nuances of semantic significance. The importance of the study of punctuation to a number of disciplines will be widely recognised as a result of the publication of this first definitive history. The first part of Pause and Effect identifies the graphic symbols and deals with their history. It covers the antecedents of the repertory of symbols, as well as the ways in which the repertory was refined and augmented with new symbols to meet changing requirements. The second part offers a short general account of the principal in...
Extracellular and Intracellular Signaling
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
The Neutral Theory of Molecular Evolution
Motoo Kimura, as founder of the neutral theory, is uniquely placed to write this book. He first proposed the theory in 1968 to explain the unexpectedly high rate of evolutionary change and very large amount of intraspecific variability at the molecular level that had been uncovered by new techniques in molecular biology. The theory - which asserts that the great majority of evolutionary changes at the molecular level are caused not by Darwinian selection but by random drift of selectively neutral mutants - has caused controversy ever since. This book is the first comprehensive treatment of this subject and the author synthesises a wealth of material - ranging from a historical perspective, through recent molecular discoveries, to sophisticated mathematical arguments - all presented in a most lucid manner.
A grammar of modern Indo-European
A Grammar of Modern Indo-European is a complete reference guide to a living Indo-European language. It contains a comprehensive description of Proto-Indo-European grammar, and offers an analysis of the complexities of the prehistoric language and its reconstruction from its descendant languages. Written in a fresh and accessible style, and illustrated with maps, figures and tables, this book focusses on the real patterns of use of Late Indo-European. The book is well organised and is filled with full, clear explanations of areas of confusion and difficulty. It also contains an extensive English - Indo-European, Indo-European - English vocabulary, as well as detailed etymological notes, designed to provide readers with an easy access to the information they require.An essential reference source for the student of Indo-European as a learned and living language, this work will appeal to students of languages, classics, and the ancient world, as well as to general readers interested in the history of language, and in speaking the direct ancestor of the world's largest language family.
A Dynasty of Monsters
Get an insight into one of the newest threats to the Mortal Realms – the monstrous vampire queen Lauka Vai and her dynasty of terrifying, bloodthirsty killers. The Colonnade, a free city held aloft by gargantuan pillars and crowned with a spire of diamonds, is the jewel of Ghur, obsessed with purity in a realm of bestial savagery. But now, it faces annihilation at the hands of an unstoppable beastherd. In a desperate gamble, Councillor Atella Reigehren requests the aid of a being anathema to the Colonnade. She seeks Lauka Vai, the Mother of Nightmares, and her dynasty of monsters, the Avengorii. The crucible of war has thrown these factions together, but can they put their differences aside to face this common foe, or will the clash of purity and monstrosity be their undoing?
Statistical Methods in Molecular Evolution
In the field of molecular evolution, inferences about past evolutionary events are made using molecular data from currently living species. With the availability of genomic data from multiple related species, molecular evolution has become one of the most active and fastest growing fields of study in genomics and bioinformatics. Most studies in molecular evolution rely heavily on statistical procedures based on stochastic process modelling and advanced computational methods including high-dimensional numerical optimization and Markov Chain Monte Carlo. This book provides an overview of the statistical theory and methods used in studies of molecular evolution. It includes an introductory sect...
The Selma of the North
Between 1958 and 1970, a distinctive movement for racial justice emerged from unique circumstances in Milwaukee. A series of local leaders inspired growing numbers of people to participate in campaigns against employment and housing discrimination, segregated public schools, the membership of public officials in discriminatory organizations, welfare cuts, and police brutality. The Milwaukee movement culminated in the dramaticÑand sometimes violentÑ1967 open housing campaign. A white Catholic priest, James Groppi, led the NAACP Youth Council and Commandos in a militant struggle that lasted for 200 consecutive nights and provoked the ire of thousands of white residents. After working-class m...
Dialogues on Perception
An elucidation of ideas and insights generated by the paradigm of "early vision," presented in the form of dialogues.
