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Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory...
Accompanying CD-ROM (in v. 2) has image collections which can be saved in PowerPoint or HTML.
Graduate-level exposition by noted Russian mathematician offers rigorous, readable coverage of classification of equations, hyperbolic equations, elliptic equations, and parabolic equations. Translated from the Russian by A. Shenitzer.
New discoveries in the field of stem cell research have frequently appeared in the news and in scientific literature. Research in this area promises to lead to new therapies for cancer, heart disease, diabetes, and a wide variety of other diseases. This two-volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system. The editors of the Handbook of Stem Cells include: Robert Lanza...
The new series, International Mathematical Series founded by Kluwer / Plenum Publishers and the Russian publisher, Tamara Rozhkovskaya is published simultaneously in English and in Russian and starts with two volumes dedicated to the famous Russian mathematician Professor Olga Aleksandrovna Ladyzhenskaya, on the occasion of her 80th birthday. O.A. Ladyzhenskaya graduated from the Moscow State University. But throughout her career she has been closely connected with St. Petersburg where she works at the V.A. Steklov Mathematical Institute of the Russian Academy of Sciences. Many generations of mathematicians have become familiar with the nonlinear theory of partial differential equations read...
The most daring commando operation of World War II from which no one can return... On a June night in 1944, ten German officers of Baltic origin is parachuted out of a Dornier plane near Moscow. Their mission: penetrate the Kremlin and eliminate Stalin. A fascinating novel inspired by a documented adventure that is as heroic as it is senseless. Perfect for war fiction fanatics and fans of Anthony Doerr's "All the Light We Cannot See". Heinz G. Konsalik (1921-1999), a prolific German novelist known for his humanistic depictions of war, became famous for "The Doctor of Stalingrad." With 155 novels and 83 million copies sold, he remains a celebrated figure of post-war German literature.
Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.
During the last few years, tremendous progress has been made in understanding various aspects of pre-mRNA processing. This book, with contributions from leading scientists in this area, summarizes recent advances in nuclear pre-mRNA processing in plants. It provides researchers in the field, as well as those in related areas, with an up-to-date and comprehensive, yet concise, overview of the current status and future potential of this research in understanding plant biology.
This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors