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Brain Injury
Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury. This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.
Ion Channels
A wealth of information has been accumulated about the function of ion channels of excitable cells since the extensive and pioneering voltage clamp studies by Hodgkin, Huxley, and Katz 36 years ago. The study of ion chan nels has now reached a stage at which a quantum jump in progress is antici pated. There are many good reasons for this. Patch clamp techniques origi nally developed by Neher and Sakmann 12 years ago have made it possible to study the function of ion channels in a variety of cells. Membrane ionic currents can now be recorded practically from many types of cells using the whole-cell patch clamp technique. The opening and closing of individual ion channels can be analyzed using...
Mitochondria in Pathogenesis
Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.
Illuminating the Afterlife
We all want to know what happens when we die. According to Cyndi Dale, we don't have to wait to find out. With Illuminating the Afterlife, this internationally renowned author presents a compelling investigation of the soul's journey - an evolutionary cycle of birth, death, and rebirth that we travel as we ascend through the spiritual "Planes of Light."
Neurodegenerative Diseases
Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995
Emerging Drugs and Targets for Parkinson's Disease
This exemplary new book reviews some of the most outstanding examples of new drugs currently in pharmaceutical development or new targets under the validation process to try to reach the Parkinson ́s drug market in the next few years as potential disease modifying drugs.
Drug-Induced Mitochondrial Dysfunction
This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.
UK Directory of Executive Recruitment
The UK Directory of Executive Recruitment is a comprehensive source of information on the UK's executive search and selection consultancies.
Never See a Need
Never See a Need is an account of the lives and works of the Sisters of St Joseph of the Sacred Heart in South Australia from the time of their foundation in 1866 until Mary MacKillop's canonisation in 2010. Much happened during those 144 years. There were dark times and bright times, times of growth and expansion interspersed with times of decline, times of stability and times of change, and through it all, the members of the Congregation never forgot their call to do what they could to remedy the evils and ills of their society. They were educators, but they also looked out for the welfare of the poor and disadvantaged in different ways as they moved across the landscape to wherever they were needed, always a "people on the move" but always stable in their devotion to their ministry.
CNS Neurotransmitters and Neuromodulators
CNS Neurotransmitters and Neuromodulators is an indispensable and comprehensive reference for any research worker involved with glutamate in the CNS. An impressive group of well-known authors contribute up-to-date reviews that offer a global picture of the state of research in the area. The authors cover a wide range of interdisciplinary aspects of the subject, including anatomical, physiological, and biochemical. Topics in this volume range from the localization of synthetic enzymes through electrophysiology, pharmacology, and molecular biology to behavioral importance in learning and memory. No other single volume offers the depth or broad scope of material found here. In addition to being a definitive reference work, CNS Neurotransmitters and Neuromodulators is the perfect one-step introduction to glutamate in the CNS for undergraduates, postgraduates, or established researchers who want a comprehensive overview text to keep abreast of developments in several areas of neuroscience.
