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The Role of Glycosylation in Health and Disease
Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process stil...
Systems Biology
This open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology. The fully updated 2nd edition also contains information that has only become available as a result of the increase in knowledge in recent ye...
ISFRAM 2014
This book highlights research in flood related areas and sustainable management conducted by researchers around the world, compiling their innovative work in order to share best practices for managing floods and recommended flood solutions. The individual papers cover the fundamentals and latest advances in the areas of flood research and management, providing in-depth coverage complemented by illustrations, diagrams and tables. The book offers a valuable source of information on methods and state-of-the art technology for effective flood management.
The Indian Empire
None
Novel Anticancer Drug Protocols
We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy. Advances in cancer cell biology fueled by the molecular biology revolution have resulted in the uncovering of many novel potential molecular targets for cancer therapy. New anticancer drug discovery and development is now largely focused on exploiting these new molecular targets, which encompass oncogenes, tumor s- pressor genes, and their gene products, as well as targets involved in tumor angiogenesis, metastasis, survival, and longevity mechanisms. Exploitation of some of these targets has already yielded fruits and introduced new paradigms of molecularly targeted cancer therapy into the clinic, namely, protein kinase in- bition by antibodies or small molecules, exemplified by Herceptin® (trastuzumab), a humanized antibody targeted against the HER-2 growth factor receptor tyrosine kinase for the treatment of metastatic breast cancer; and Gleevec, a small molecule bcr-abl kinase inhibitor for the treatment of chronic myel- enous leukemia.
Introduction to Reticular Chemistry
A concise introduction to the chemistry and design principles behind important metal-organic frameworks and related porous materials Reticular chemistry has been applied to synthesize new classes of porous materials that are successfully used for myraid applications in areas such as gas separation, catalysis, energy, and electronics. Introduction to Reticular Chemistry gives an unique overview of the principles of the chemistry behind metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and zeolitic imidazolate frameworks (ZIFs). Written by one of the pioneers in the field, this book covers all important aspects of reticular chemistry, including design and synthesis, properti...
Synthesis of Lanthanide and Actinide Compounds
The history of the rare earths has entered its third century; trans uranium elements are now a half century old. Both the lanthanide and actinide ele ments, 30 elements altogether, are f elements, meaninj that their metallic 2 1 1 electronic configurations are typically 6s 5d 4f" and 7s 6d 5f" respectively. To an elementary approximation as summarized in the 'average inorganic chemistry textbook, these configurations cause their chemistry to be described by the trivalent state accompanied by less interesting effects such as the lanthanide contraction. However, the discovery of divalent and tetravalent lanthanides and di- to seven-valent actinides hinted at the existence of more interesting although still classic solid-state and coor dination chemistry. Metallic halides and chalcogenides and electron-poor cluster compounds have been the outgrowth of many synthetic efforts during the past 25 years or so. These days, one can say that the lan thanides and actinides are not at all boring; the fascination arises from every element being an individual, having its own chemistry.
Urinary Bladder Pathology
This book focuses on bladder cancer pathology, including primary bladder malignancies and other tumor varieties, with an emphasis on diagnostic pitfalls and clinical relevance. It also describes normal bladder histology, benign abnormalities with cancer mimickers, and cancer carcinogenesis, which are important subject matter for understanding bladder cancers, correct diagnosis, and differential diagnoses. Accurate diagnosis of bladder cancer plays a central role in daily pathology practice, clinical management, and prognosis. Advances in immunohistochemistry and molecular pathology have enhanced the accuracy of cancer pathology diagnoses. In addition to covering the anatomic and histologic features of bladder tumors, this book also reviews recent molecular and immunohistochemical advances in these areas. Recently updated clinical management information is also presented in this book. Written by experts in the field, Urinary Bladder Pathology serves as a useful resource for practicing pathologists, pathology trainees, and other health professionals who treat patients with bladder cancers.
