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Notch Signaling as a Regulator of Tumor Immune Response
  • Language: en
  • Pages: 193
Thymus Function and Aging: A Focus on Thymic Epithelial Cells
  • Language: en
  • Pages: 129
Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment
  • Language: en
  • Pages: 499

Advances in the Molecular Mechanisms in Gastrointestinal Tumorigenesis and Treatment

Gastrointestinal (GI) cancer, the group of cancers that affect the gastrointestinal tract and other organs that are contained within the digestive system, including the esophagus, pancreas, stomach, colon, rectum, anus, liver, biliary system and small intestine, is the most common malignant diseases with high mortality rates, leading to a substantial burden on public health and healthcare systems around the world. Diverse subtypes of GI cancer impressively exhibit similar characteristics like high frequency oncogenic mutation burden, early metastatic potency, chemo-resistance and immunotherapeutic tolerance indicating a possible unique tumorigenic mechanism.

Molecular Mechanisms of Notch Signaling
  • Language: en
  • Pages: 417

Molecular Mechanisms of Notch Signaling

  • Type: Book
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  • Published: 2018-07-20
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  • Publisher: Springer

This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

Hedgehog Signaling
  • Language: en
  • Pages: 571

Hedgehog Signaling

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hedgehog signaling. - Contributions from leading authorities - Informs and updates on all the latest developments in the field

The Immune Escape Mechanism and Novel Immunotherapeutic Strategies of Leukemia
  • Language: en
  • Pages: 177
Targeting Developmental Pathways in Inflammation and Disease
  • Language: en
  • Pages: 291
The Gene Knockout Factsbook, Two-Volume Set
  • Language: en
  • Pages: 1163

The Gene Knockout Factsbook, Two-Volume Set

The FactsBooks Series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "a growing series of excellent manuals" by Molecular Medicine Today, and "essential works of reference" by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format and drawing from meticulous research, the Factsbooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. The Gene Knockout FactsBook contains entries, grouped into subject disciplines, covering immunology, neurobiology, development, cancer, and other knockouts. It describes more than 600 gene knockouts described and listed in alphabetical order for easy reference.Key Features* Entries provide information on:* general description of the protein and its function* gene symbol and database accession number* knockout construct* mouse phenotype* key references

The Journal of Cell Biology
  • Language: en
  • Pages: 528

The Journal of Cell Biology

  • Type: Book
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  • Published: 1995
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  • Publisher: Unknown

No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-

Proceedings of the National Academy of Sciences of the United States of America
  • Language: en
  • Pages: 1384

Proceedings of the National Academy of Sciences of the United States of America

  • Type: Book
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  • Published: 2004
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  • Publisher: Unknown

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