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'This six-book series looks likely to become a landmark in historical fiction' THE TIMES 'With characteristic verve and stunning period detail, this novel will captivate you and break your heart. Utterly sublime' TRACY BORMAN Alison Weir, historian and author of the Sunday Times-bestselling Six Tudor Queens series, relates one of the most tragic stories in English history: Katheryn Howard, Henry VIII's fifth queen. 'Conveys the heart-rending pathos of a young woman executed, whose only real crime was her naïveté and her desire to be loved... It is a profoundly moving story that lingers long after the last page is turned' ELIZABETH FREMANTLE 'Alison's sensitively drawn novel will change eve...
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Biological Response Modifiers: New Approaches to Disease Intervention focuses on biological response modifiers (BRMs) and the ways they provide novel approaches to disease control. It examines how BRMs act through an organism's own biological response mechanisms and how their mechanisms of action can be utilized to develop new modalities of chemotherapy. Organized into 15 chapters, this volume begins with an overview of specific agents and approaches to biological therapy, the basic concepts of immunity, and BRM screening. It then discusses interferons and their immunoregulatory functions; mechanism of interferon action; how nucleic acids and polynucleotides regulate the immune system; clini...
101 Textures in Colored Pencil provides step-by-step instruction and examples of a multitude of textures for creating realistic masterpieces in colored pencil.
This is a must-read book for all students studying early childhood at a range of levels and practitioners who are looking to deepen their understanding of play and playful practices.