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Cardiac Arrhythmias
The most intimate mechanisms of cardiac arrhythmias are still quite unknown to scientists. Genetic studies on ionic alterations, the electrocardiographic features of cardiac rhythm and an arsenal of diagnostic tests have done more in the last five years than in all the history of cardiology. Similarly, therapy to prevent or cure such diseases is growing rapidly day by day. In this book the reader will be able to see with brighter light some of these intimate mechanisms of production, as well as cutting-edge therapies to date. Genetic studies, electrophysiological and electrocardiographyc features, ion channel alterations, heart diseases still unknown , and even the relationship between the psychic sphere and the heart have been exposed in this book. It deserves to be read!
Basis and Treatment of Cardiac Arrhythmias
Incorporating the information related to mechanisms and treatment of cardiac arrhythmia, this book discusses genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These approaches and implementations of anti-arrhythmic therapy derive from many decades of research.
Heart Rate and Rhythm
Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.
Signal Transducers and Activators of Transcription (STATs)
The only fully comprehensive reference for STAT proteins and their biology, this book describes the current state of ongoing research in this broad area, and looks toward the future to try to predict the discoveries that lie ahead.
Concepts in Biology
This book provides a comprehensive review of the history of concepts of the endocrine, nervous and immune systems throughout the last century. Historically, these systems were long considered as compartments that performed separate and different functions. However, a breakthrough occurred when advances in genetics and cellular and molecular biology techniques revealed that these systems shared molecular entities (such as cytokines, hormones and neurotransmitters) with their cognate receptors. These molecular links between the three systems broaden our understanding of the regulation of physiological processes. This approach has generated a multiplicity of new concepts, including crosstalk be...
Inflammation in Psychiatry
An innovative and integrative avenue toward understanding and treating mental health disorders Psychoimmunology is a rapidly maturing area of scientific endeavor that provides a compelling integrative link between the immune system and its response to stress and psychiatric illness. Stress initiates pathological changes by activating the immune and endocrine systems. Inflammation is at the core of the complex and interactive systems that both contribute to and result from psychopathology. Consequently, inflammation research advances our knowledge of the pathology of depression, schizophrenia, chronic fatigue syndrome, posttraumatic stress disorder and a host of co- morbid conditions, notably...
Bioactive Natural Products (Part G)
Bioactive Natural Products (Part G)
Functional Imaging and Modeling of the Heart
This book constitutes the refereed proceedings of the Third International Workshop on Functional Imaging and Modeling of the Heart, FIMH 2005, held in Barcelona, Spain in June 2005. The 47 revised full papers presented were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on modeling of the heart: anatomy extraction and description; electro-physiology and electro- and magnetography; modeling of the cardiac mechanisms and functions; and cardiac motion estimation.
Melatonin
Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This important book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.
Primordial Cosmology
Primordial Cosmology deals with one of the most puzzling and fascinating topics debated in modern physics - the nature of the Big Bang singularity. The authors provide a self-consistent and complete treatment of the very early Universe dynamics, passing through a concise discussion of the Standard Cosmological Model, a precise characterization of the role played by the theory of inflation, up to a detailed analysis of the anisotropic and inhomogeneous cosmological models. The most peculiar feature of this book is its uniqueness in treating advanced topics of quantum cosmology with a well-traced link to more canonical and pedagogical notions of fundamental cosmology. This book traces clearly the backward temporal evolution of the Universe, starting with the Robertsonndash;Walker geometry and ending with the recent results of loop quantum cosmology in view of the Big Bounce. The reader is accompanied in this journey by an initial technical presentation which, thanks to the fundamental tools given earlier in the book, never seems heavy or obscure.
