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Modern drug design and testing involves experimental in vivo and in vitro measurement of the drug candidate's ADMET (adsorption, distribution, metabolism, elimination and toxicity) properties in the early stages of drug discovery. Only a small percentage of the proposed drug candidates receive government approval and reach the market place. Unfavorable pharmacokinetic properties, poor bioavailability and efficacy, low solubility, adverse side effects and toxicity concerns account for many of the drug failures encountered in the pharmaceutical industry. Authors from several countries have contributed chapters detailing regulatory policies, pharmaceutical concerns and clinical practices in their respective countries with the expectation that the open exchange of scientific results and ideas presented in this book will lead to improved pharmaceutical products.
Though relatively small in number until the latter decades of the nineteenth century, Houston'sHispanic population possesses a rich and varied history that has previously not been readily associated in the popular imagination with Houston. However, in 1989, the first edition of Thomas H. Kreneck’s Del Pueblo vividly captured the depth and breadth of Houston’s Hispanic people, illustrating both the obstacles and the triumphs that characterized this vital community’s rise to prominence during the twentieth century. This new, revised edition of Del Pueblo: A History of Houston’s Hispanic Community updates that vibrant history, incorporating research on trends and changes through the beg...
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