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Genomics, Proteomics and Vaccines
While the sequence of the human genome sequence has hit the headlines, extensive exploitation of this for practical applications is still to come. Genomic and post-genomic technologies applied to viral and bacterial pathogens, which are almost equally important from a scientific perspective, have the potential to be translated into useful products and processes much more rapidly. Genomics, Proteomics and Vaccines introduces the history of vaccinology and discusses how vaccines are expected to evolve in the future. It describes the relevant technologies, including genome sequencing and analysis, DNA microarrays, 2D electrophoresis and 2D chromatography, mass spectrometry and high-throughput protein expression and purification. The book also features examples of the exploitation of genomics and post-genomics in vaccine discovery, and contains useful descriptions of the biology and pathogenesis of clinically important bacterial pathogens. This book should be of interest to all those working in vaccine discovery and development in pharmaceutical and biotechnology companies as well as in academic institutions
Concepts in Bacterial Virulence
Over the past few decades the increase in bacterial resistance has led to the search for novel antibacterial therapies and a better understanding of virulence mechanisms used by pathogens. It has been shown that the interplay between pathogenic bacteria and the host is complex and finely balanced. Successful pathogens can manipulate host homeostasis and normal cell functions using a variety of molecular strategies. This volume of the Karger book series Contributions to Microbiology summarizes some of the most important bacterial virulence mechanisms. Eminent scientists provide an update on recent findings in their fields. This state-of-the-art account will not only attract the interest of clinical and preclinical researchers, but will also be of great value to students with an interest in medicine, biology, chemistry, and infectious diseases.
The Enzymes
Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.
Coevolution of Animals and Plants
It has long been recognized that plants and animals profoundly affect one another’s characteristics during the course of evolution. However, the importance of coevolution as a dynamic process involving such diverse factors as chemical communication, population structure and dynamics, energetics, and the evolution, structure, and functioning of ecosystems has been widely recognized for a comparatively short time. Coevolution represents a point of view about the structure of nature that only began to be fully explored in the late twentieth century. The papers presented here herald its emergence as an important and promising field of biological research. Coevolution of Animals and Plants is t...
Salmonella in Domestic Animals
Salmonella remains a major cause of economic loss in domestic livestock and human food poisoning worldwide. In the last 10 years there have been major advances in understanding the salmonella organism, meaning a compiled source of the new research is urgently needed. With fully updated chapters and new coverage of genome structure, virulence, vaccine development, molecular methods for epidemiology and exotics, this second edition is an invaluable resource for researchers of animal and human health.
