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The Reliquary
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Women's Mood Disorders
This text provides background on the history of perinatal psychiatry, and discusses future directions in the field. It clearly defines perinatal mood and anxiety disorders (PMADs), which are the most common complication of pregnancy. When left untreated, PMADs are morbid and devastating for both the patient and their entire family. It reviews gold standard recommendations for the treatment of PMADs, including evidence-based psychotherapies, as well as risk-benefit analysis of psychotropic medication use in pregnancy and lactation. Additionally, common presentations of depression, anxiety, and trauma in pregnancy and postpartum women, as well as mania, psychosis, suicidal and homicidal though...
Mass Spectrometry for Drug Discovery and Drug Development
Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an ov...
Bulletin
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Mitochondria: the cell powerhouse and nexus of stress
Mitochondrion, a sub-cellular organelle originated from primary endosymbiosis, plays a vital role in energy metabolism of eukaryotic cells. The transfer of electrons through the electron transport chain (ETC) to molecular oxygen accompanied by the extrusion of protons from the matrix generate an electrochemical gradient across the inner mitochondrial membrane (IMM) that is used for ATP synthesis by oxidative phosphorylation. Despite many aspects of ATP synthesis have been delineated, regulatory mechanisms responsible for energy synthesis and transfer still remain to be uncovered. In addition to energy function, mitochondria play a crucial role in cell metabolism under both physiological and ...
Colonoscopy
First Edition - Winner of 2004 BMA Medical Book Competition in Gastroenterology The second edition of this prize winning book is written by some of the world's foremost experts in the field of colonoscopy and colonic imaging. Every chapter has been updated and 5 new chapters have been added to include the latest information and advances in the field of colonoscopy: Capsule Colonoscopy Narrow Band Imaging Confocal Endomicroscopy Endoscopic Submucosal Dissection in the Colon New Colonoscopes and Assist Devices Drawing on the vast experience of the authors it covers every area of medicine that impacts on colonoscopy, including virtual colonography, pathology, techniques for pediatric and adult ...
Mass Spectrometry in Medicinal Chemistry
This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.
Scaphoid Fractures
Get a quick, expert overview of current diagnosis and management of scaphoid fractures with this concise, practical resource by Drs. Geert Buijze and Jesse B. Jupiter. This easy-to-read reference presents a summary of today's best evidence-based approaches to diagnosis and management in this critical area. - Provides must-know information on scaphoid fractures, including how to apply evidence-based management, anatomy, diagnosis, acute fracture management, malunion treatment, and nonunion management. - Presents case scenarios followed by discussions of the importance of the problem, current opinion, evidence, and key recommendations. - Consolidates today's evidence-based information on scaphoid fractures into one convenient resource.
