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Robert Mayer and the Conservation of Energy
The principle of the conservation of energy was among the most important developments of nineteenth-century physics, and Robert Mayer, a physician from a small city in Germany, was one of its codiscoverers. As ship's doctor on a voyage to the Dutch East Indies in 1840, Mayer noticed that the venous blood he let from a European seaman was lighter than he expected. This observation set off a train of reflections that led him first to conclude that there must be a quantitative relationship between heat and "motion" and then, over several years, to believe in the indestructibility and uncreatability of "force." Rejecting the commonly invoked influence of Naturphilosophie, Kenneth Caneva provides...
Nanomedicine - Basic and Clinical Applications in Diagnostics and Therapy
Nanomedicine - the application of nanotechnology to human health - is a promising field of research at the interface of physical, chemical, biological, and medical science. Recent advances have made it possible to analyze biological systems at cellular and subcellular levels, offering numerous promising approaches to improve medical diagnosis and therapy. It is expected that nanomedicine will have a great impact especially on drug delivery and imaging. In this context, the development of targeted, highly specific nanoparticles is of pivotal importance. The results of these advances will offer personalized diagnostic tools and treatments in the future. Based on the 2nd Else Kröner-Fresenius-...
Interphase Between Aging and Neurodegenerative Diseases
The purpose of this Research Topic is to discuss the latest developments in aging and neurodegenerative diseases. Aging represents the major risk factor of the two most relevant neurodegenerative diseases Parkinson’s disease (PD) and Alzheimer’s disease (AD). It is generally accepted that symptoms of PD correlate with the severity of degeneration of dopaminergic substantia nigra neurons. In most cases neuronal loss during aging is not sufficient to cause clinical symptoms but only leads to a preclinical state of PD. However, in a small number of our population, neurodegeneration by aging gets accelerated by individual (e.g. brain injuries), environmental (e.g. toxins) and genetic (e.g. m...
Money, Macroeconomics and Keynes
This volume, along with its companion volume, Methodology, Microeconomics and Keynes is published in honour of Victoria Chick, inspired by her own contributions to knowledge in all of these areas and their interconnections. It represents both consolidation and the breaking of new ground in Keynesian monetary theory and macroeconomics by leading figures in these fields.
Cultural Memory and Early Civilization
Now available to an English-speaking audience, this book presents a groundbreaking theoretical analysis of memory, identity and culture. It investigates how cultures remember, arguing that human memory exists and is communicated in two ways, namely inter-human interaction and in external systems of notation, such as writing, which can span generations. Dr Assmann defines two theoretical concepts of cultural memory, differentiating between the long-term memory of societies, which can span up to 3,000 years, and communicative memory, which is typically restricted to 80 to 100 years. He applies this theoretical framework to case studies of four specific cultures, illustrating the function contexts and specific achievements, including the state, international law, religion and science. Ultimately, his research demonstrates that memory is not simply a means of retaining information, but rather a force that can shape cultural identity and allow cultures to respond creatively to both daily challenges and catastrophic changes.
Hydrophiloidea (Coleoptera)
Concerns about global biodiversity are rising dramatically, yet we are lagging behind in the most basic prerequisite for its understanding and conservation: the inventory. Insect species may make up five or ten times the number of all other plant and animal species combined, and as such they represent one of the major challenges in biosystematic science. World Catalogue of Insects is an initiative aiming at compiling worldscale, authoritative catalogues of monophyletic insect taxa. We are therefore proud to launch this major series. Volumes will as a minimum contain standard nomenclatoral information on all names pertaining to the taxon treated, including type locality and distribution to the extent this is relevant. Additional information is optional, e. g., location, status and condition of types; biology; bibliographical information; pest status; vector status; etc. This volume two focuses on Hydrophiloidea (Coleoptera). (Series: World Catalogue of Insects)
Recent Concepts in Sarcoma Treatment
There have been significant advances in the treatment of sarcomas in the past several years. Further, different clini cal treatment programs are being advocated in different areas including surgery alone, surgery with preoperative or post operative chemotherapy, surgery with different radiotherapy modalities, with each investigator espousing his own treat ment program. On the other side, there is the question of whether these treatment programs are offering better results or whether the natural history of sarcomas has changed. The International Symposium on Sarcomas was held at Innisbrook Resort, Tarpon Springs, Florida, October 8-10, 1987. This was the first international symposium to date ...
Interleukin-27: Biological Properties and Clinical Application
This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
Minimal Access Surgery in Oncology
(Greenwich Medical Media, LTD.) Comprehensive text giving a scientific appraisal of the oncolog- ical acceptability of performing cancer surgery using a minimalist approach. For oncologists. Color illustrations.
