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The Major Discoveries of Cajal and His Disciples: Consolidated Milestones for the Neuroscience of the XXIst Century
When Santiago Ramón y Cajal started to unravel the fine structure of the nervous system in the last decades of the XIXth century maybe only his unbeatable soul of brave Spaniard imagined that most of the descriptions were scientific truths that lasted to date. Simple histological stainings, curiosity to ameliorate these, monocular microscopes, patience for drawing his observations and a rich imaginative open mind: this is the recipy for Cajal success. His descriptions of connectivity in the nervous system, compiled in Cajal's opus magna published in 1904 ("Textura del sistema nervioso del hombre y los vertebrados") and 1911 ("Histologie du systeme nerveux"), have been corroborated by modern...
Vestibular Dysfunction and Its Therapy
The book provides the first comprehensive, multidisciplinary approach to the topic for all involved in the diagnosis and therapy: physicians (neurologists, otorhinolaryngologists, ophthalmologists), physical therapists and orthoptic assistants. A comprehensive review of basic mechanisms, as well as the clinical picture and its therapy are given. It also is valuable for scientists in basic research who want to relate oculomotor, vestibular and neuropharmacological results to their findings. Topics covered are: anatomy, neurophysiology and neurotransmitters relevant for the generation of eye movements in the vestibular nuclei and other brainstem areas including the cerebellum; peripheral vestibular disorders and their therapy; a complete overview on vestibular compensation, which forms the basis for therapy in vestibular neuritis; the now well understood mechanisms of benign paroxysmal positional vertigo (BPPV) and its effective therapy; pathophysiology and therapeutical principles in Menières disease; latest information on treatment for involuntary eye movements of central origin.
Visual Perception Part 1
This book presents a collection of articles reflecting state-of-the-art research in visual perception, specifically concentrating on neural correlates of perception. Each section addresses one of the main topics in vision research today. Volume 1 Fundamentals of Vision: Low and Mid-Level Processes in Perception covers topics from receptive field analyses to shape perception and eye movements. A variety of methodological approaches are represented, including single-neuron recordings, fMRI and optical imaging, psychophysics, eye movement characterization and computational modelling. The contributions will provide the reader with a valuable perspective on the current status of vision research, and more importantly, with critical insight into future research directions and the discoveries yet to come.· Provides a detailed breakdown of the neural and psychophysical bases of Perception · Presents never-before-published original discoveries · Includes multiple full-color illustrations
The Cerebellum: From Development to Learning
In this book, laboratory leaders on cerebellar neuroscience have revised the present body of knowledge about cerebellum anatomy and function. The trip throughout the cerebellar vineyard organization starts from the causal study of morphogenesis (that is, the molecular and cellular mechanisms underplaying form generation) to the molecular mechanism regulation cellular differentiation: Basson, Dusart, Hawkes, Martinez and Rosi’s groups contributions. Then, neurodevelopmental anomalies associated with structural disorganization are revised in Jissendi and Batkovich’s group reviews, describing and discussing pathogenic processes. Finally, functional mechanisms of cerebellar circuits involved in motor learning are revised by Delgado-Garcia and Armengol’s group contribution.
Interval Timing and Time-Based Decision Making
The perception of time is crucial for everyday activities from the sleep–wake cycle to playing and appreciating music, verbal communication, to the determination of the value of a particular behavior. With regard to the last point, making decisions is heavily influenced by the duration of the various options, the duration of the expected delays for receiving the options, and the time constraints for making a choice. Recent advances suggest that the brain represents time in a distributed manner and reflects time as a result of temporal changes in network states and/or by the coincidence detection of the phase of different neural populations. Moreover, intrinsic oscillatory properties of neu...
Emerging Drugs and Targets for Multiple Sclerosis
Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of the disease – demyelination of axons through remyelination therapies. Due to several recent breakthroughs in the understanding of the pathophysiology of MS new targets for remyelination and immunomodulation are rapidly emerging. This book provides a comprehensive overview of drug discovery and development for the molecular basis of the disease, from new targets to drugs currently in clinical development, cellular and animal disease models to biomarkers for diagnosis and assessment in clinical trials. Emerging Drugs and Targets for Multiple Sclerosis is an ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
