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Drug Design
This book provides a complete snapshot of various experimental approaches to structure-based and ligand-based drug design and is illustrated with more than 200 images.
Drug Design
Structure-based (SBDD) and ligand-based (LBDD) drug design are extremely important and active areas of research in both the academic and commercial realms. This book provides a complete snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include X-ray crystallography, NMR, fragment-based drug design, free energy methods, docking and scoring, linear-scaling quantum calculations, QSAR, pharmacophore methods, computational ADME-Tox, and drug discovery case studies. A variety of authors from academic and commercial institutions all over the world have contributed to this book, which is illustrated with more than 200 images. This is the only book to cover the subject of structure and ligand-based drug design, and it provides the most up-to-date information on a wide range of topics for the practising computational chemist, medicinal chemist, or structural biologist. Professor Kenneth Merz has been selected as the recipient of the 2010 ACS Award for Computers in Chemical & Pharmaceutical Research that recognizes the advances he has made in the use of quantum mechanics to solve biological and drug discovery problems.
Nuclear and Particle Astrophysics
What is the Universe made of? How old is it? How does a supernova explode? Can we detect black holes? And where do cosmic rays originate? This volume provides a comprehensive and pedagogical introduction to modern ideas and challenging problems in nuclear and particle astrophysics. Based on a graduate school, specially written articles by eight leading experts cover a wealth of exciting topics, including the search for black holes, nucleosynthesis and neutrino transport in supernovae, the physics of neutron stars, massive neutrinos, cosmic ray physics and astrophysics, and physical cosmology. Together, they present the Universe as a laboratory for testing cutting-edge physics and bridge the gap between conference proceedings and specialised monographs. This volume provides an invaluable resource for graduate students and active researchers in nuclear and particle physics, astrophysics and cosmology.
Z° Physics
Proceedings of a NATO ASI held in Cargese, France, August 13--25, 1990
Currents in Astrophysics and Cosmology
Currents in Astrophysics and Cosmology focuses primarily on cosmic-ray physics, X-ray, gamma-ray and neutrino astronomy and cosmology, the main research areas of Professor Maurice M. Shapiro, whose 75th birthday the collection of articles celebrates. Professor Shapiro is internationally distinguished for his contributions to the development of cosmic-ray physics. Each chapter is written by a leading scientist in the field. The scope extends from the inner solar system to distant radio galaxies. The book is ideal for graduate students and scientists working in cosmic-ray astrophysics. This valuable survey will be welcomed not only for its articles by world-renowned scientists but also for its coverage of many topics in high-energy astrophysics, the combination of which makes the book unique.
Unity Of Forces In The Universe (In 2 Volumes)
We are now closer than ever to the fundamental goal of physics of understanding all physical phenomena as the inevitable consequences of few simple principles. The grand unified theory of the strong, weak and electromagnetic interactions has, among other things, explained the quantization of charge, determined the magnitude of the neutral current, and had dramatic impact on cosmology. This book is designed to bring interested students and researchers rapidly up to the point where they can contribute to this exciting field. A substantial text provides a review of the subject. In particular, several chapters are devoted to cosmology and the theory of galaxy formation. A selection of original papers is reprinted. A brief review of group theory is also provided. It is a must for all students and researchers in the field.
The Light Element Abundances
This is the first volume of a series on a regular up-to-date coverage of important developments in astronomy and astrophysics jointly published by ESO and Springer-Verlag. Here the reader finds a thorough review of the abundances of the elements up to Boron. Special emphasis is laid on primordial abundances of interest to cosmologists in particular, and on stellar production or destruction respectively. The articles written for researchers and graduate students cover theory and most recent data from telescope observations.
Current Trends In Condensed Matter, Particle Physics And Cosmology - Proceedings Of The First Bcspin Kathmandu Summer School
This volume contains the most important lecture notes by experts from condensed matter, particle physics and cosmology and is a MUST for young researchers and graduate students.While covering frontier developments in condensed matter physics, particle physics and cosmology, this school aims to bring out their interdisciplinary nature by emphasizing certain topics such as spontaneous symmetry breaking and renormalization group through a pedagogical set of lectures. In the condensed matter area, the school covered, in the first two weeks, experimental aspects of high temperature superconductivity and its possible applications.
