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For more than 60 years, the Californian Family Hinman has exercised a very considerable influence on the development and practice of the highest grade of urology, not only in the American West but worldwide. The leitmotiv of the Hinman School has been honest and thoughtful consideration of the problems of the genitourinary system gone awry. Character is the quintessence of the Hinmans. This virtue distinguishes the present volume on benign pros tatic hypertrophy assembled and edited by Frank Hinman, Jr. I first came under the spell of Frank Hinman, Sr. via his classic studies of renal counterbalance. In brief, in an experimental animal the ureter of one kidney was ligated and the subsequent ...
The physiological magnetic resonance techniques of diffusion imaging, perfusion imaging and spectroscopy offer insights into brain structure, function and metabolism. Until recently, they were mainly applied within the realm of medical research, but with their increasing availability on clinical MRI machines, they are now coming into clinical practice for the evaluation of neuropathology in individual patients. This book provides the reader with a thorough review of the underlying physical principles of each of these methods, as well as comprehensive coverage of their clinical applications. Topics covered include single- and multiple-voxel MRS techniques, MR perfusion based on both arterial spin labelling and dynamic bolus tracking approaches, and diffusion-weighted imaging, including techniques for mapping brain white matter fiber bundles. Clinical applications are reviewed in depth for each technique, with case reports included throughout the book. Attention is also drawn to possible artifacts and pitfalls associated with these techniques.
Education is a societal matter and takes place in relation to societal changes. Today, in many countries, it has to grapple with diversity and differences brought about by migration and changes in gender relations. Questions of values, human rights and the role of religions are raised. In this book scholars from Sweden, Norway, Germany, Great Britain, Canada, Namibia and South Africa discuss the issues above. Similarities as well as differences are highlighted. The varied contributors engage in a North-South dialogue. Among the questions addressed are: Can the Scandinavian countries be understood as more religious than their up-to-date, seemingly secularist reputation has led us to believe? ...
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This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental, and hypoxic/ischemic causes. The introductory chapters give an overview of the development of the human brain and the spinal cord, the mechanisms of development as obtained in experimental studies of various invertebrates and vertebrates, and the causes of congenital malformations. In the main part, the developmental disorders of the human brain and the spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These are underlined by carefully chosen clinical case studies, including imaging data and, when available, postmortem verification of the developmental disorders involved. Numerous color photographs and illustrations complement the text. This second edition emphasizes the prenatal diagnosis by ultrasound, MRI, and DTI and implements new classifications of developmental disorders.
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Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.