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Controversies in Neuro-oncology
This volume brings together an interdisciplinary group of specialists to present and discuss the latest diagnostic and therapeutic concepts and current controversial issues in the management of primary and secondary brain tumors. In the first part, the latest technical developments in neuro-oncology are presented. These include the evaluation of positron-emission tomography for diagnosis, and neuronavigation and operative mapping for operation planning. Innovations in computer-assisted 3-D radiotherapy planning and in image fusioning of CT, MRT, SPECT and PET are also described. A large section of the book is devoted to the diagnosis and interdisciplinary treatment of glioblastoma, one of th...
Digital Business Leadership
This book provides specialists and executives with a clear, yet practical set of recommendations to meet the challenges of digital transformation and ensure long-term success as a leader in a primarily digital business world. The authors describe the fundamental principles of digitization and its economic opportunities and risks, integrating them into a framework of classic and new management methods. The book also explores how increasing digitization – not only of communication, but of complete value chains – has led to a need to establish a digital business leadership. Digitization is changing people and markets: it causes the upheaval of entire industries, creates new digital-centric ...
The Practice of Enterprise Modeling
This volume constitutes the proceedings of the 10th IFIP WG 8.1 Conference on the Practice of Enterprise Modeling held in November 2017 in Leuven, Belgium. The conference was created by the International Federation for Information Processing (IFIP) Working Group 8.1 to offer a forum for knowledge transfer and experience sharing between the academic and practitioner communities. The 20 full papers and 4 short papers accepted were carefully reviewed and selected from 70 submissions. They include research results, practitioner/experience reports and work-in-progress papers and were presented in 8 sessions covering diverse topics related to enterprise modelling and its application in practice.
Global Manufacturing Management
Using site-specific optimization approaches in international manufacturing networks is increasingly proving insufficient. To solve this problem, several holistic and integrated alternatives have been developed to reflect a global perspective. This book presents advances in the St. Gallen Global Manufacturing Network Model and its application in numerous industry-, benchmarking- and research projects. The contents combine data-driven solutions with qualitative management frameworks for the strategic optimization of international manufacturing networks. In the first part, the book addresses the foundation of manufacturing network management and further describes the St. Gallen Operational Exce...
Product Lifecycle Management to Support Industry 4.0
This book constitutes the refereed post-conference proceedings of the 15th IFIP WG 5.1 International Conference on Product Lifecycle Management, PLM 2018, held in Turin, Spain, in July 2018. The 72 revised full papers presented were carefully reviewed and selected from 82 submissions. The papers are organized in the following topical sections: building information modeling; collaborative environments and new product development; PLM for digital factories and cyber physical systems; ontologies and data models; education in the field of industry 4.0; product-service systems and smart products; lean organization for industry 4.0; knowledge management and information sharing; PLM infrastructure and implementation; PLM maturity, implementation and adoption; 3D printing and additive manufacturing; and modular design and products and configuration and change management.
Handbook of Pharmaceutical Granulation Technology
Integrating the basic principles and industrial practices of pharmaceutical granulation production, this book discusses technologies and demonstrates cost-effective approaches to manufacturing solid-dosage forms with content uniformity and consistent physical properties while complying with regulatory requirements. Specialists from pharmaceutical companies, academia, and the U.S. Drug Regulatory Affairs agency address current and changing practices in industrial drug granulation production. Text, charts, figures, and photographs illustrate the pros and cons of diverse methods and technologies for accurately achieving strong bonding of particles in tablets and capsules.
Granulation
Granulation provides a complete and comprehensive introduction on the state-of-the-art of granulation and how it can be applied both in an academic context and from an industrial perspective. Coupling science and engineering practices it covers differing length scales from the sub-granule level through behaviour through single granules, to bulk granule behaviour and equipment design. With special focus on a wide range of industrially relevant areas from fertilizer production, through to pharmaceuticals. Experimental data is complemented by mathematical modelling in this emerging field, allowing for a greater understanding of the basis of particle products and this important industry sector.F...
PAT Applied in Biopharmaceutical Process Development And Manufacturing
As with all of pharmaceutical production, the regulatory environment for the production of therapeutics has been changing as a direct result of the US FDA-initiated Quality by Design (QbD) guidelines and corresponding activities of the International Committee for Harmonization (ICH). Given the rapid growth in the biopharmaceutical area and the comp
Smart, Sustainable Manufacturing in an Ever-Changing World
This book presents recent developments, research results, and industrial experience to increase the knowledge base of academics and industry. In a small world where trade is the new global driving force conquering countries and continents alike, international competitiveness is becoming the ultimate challenge. It requires high-quality products manufactured with state-of-the-art technologies at low cost under the assumption of highly efficient operations management as well as clear corporate goals and strategy. This in turn is based on improved engineering training and education, relevant applied research, and an active interaction between academia and industry.
Systems, Software and Services Process Improvement
This volume constitutes the refereed proceedings of the 27th European Conference on Systems, Software and Services Process Improvement, EuroSPI conference, held in Düsseldorf, Germany, in September 2020*. The 50 full papers and 13 short papers presented were carefully reviewed and selected from 100 submissions. They are organized in topical sections on visionary papers, SPI manifesto and improvement strategies, SPI and emerging software and systems engineering paradigms, SPI and standards and safety and security norms, SPI and team performance & agile & innovation, SPI and agile, emerging software engineering paradigms, digitalisation of industry, infrastructure and e-mobility, good and bad practices in improvement, functional safety and cybersecurity, experiences with agile and lean, standards and assessment models, recent innovations, virtual reality. *The conference was partially held virtually due to the COVID-19 pandemic.
