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This text presents the pathogenesis, clinical manifestations and management of all haematological disorders. The content is logically organized from definition to treatment and the descriptions of the origins, manifestations and treatment of haematologic diseases are written in language common to clinical and basic science.
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The fifth edition of this well-known series of lectures by distinguished Harvard hematologists is substantially revised to include discussions of the many important scientific developments in contemporary hematology. New insights into oncogenes, growth factors, membrane receptors, differentiation and morphogenesis, enzymology, molecular biology, and evolutionary biology appear in virtually every lecture. A lecture on general principles of malignant disease appears for the first time in recognition of the fact that in many hospitals and medical schools hematology departments now encompass oncology - an important topic that is not covered elsewhere in the medical curriculum.This new edition also adds many tables and figures relating to differential diagnosis that will be useful to practicing physicians and house officers. Examples include causes of splenomegaly, indications for splenectomy, differential diagnosis of normocytic anemia, macrocytic anemia, hypochromic anemia, thrombocytopenia, bone marrow failure syndromes, and many others. The bibliographies have been expanded, a new appendix containing laboratory methods has been added, and there is an unusually complete index.
This book concerns the signatures left behind in chromosomes by the forces that drive DNA code evolution in the form of DNA nucleotide substitutions. Since the genetic code predetermines the molecular basis of life, it could have been about any aspect of biology. As it happens, it is largely about recent adaptation of pathogens and their human host. Nine chapters are medically oriented, two are bioinformatics-oriented and one is technological, describing the state of the art in synthetic point mutagenesis. What stands out in this book is the increasing rate at which DNA data has been amassed in the course of the past decade and how knowledge in this vibrant research field is currently being translated in the medical world.